Retrospective Study of the Protective Effect of Gastrodin on Myocardium in Patients Undergoing Cardiac Surgery

Cardiac Surgical Procedures Clinical Trial

Official title:

Retrospective Study of the Protective Effect of Gastrodin on Myocardium in Patients Undergoing Cardiac Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06012994
• Other study ID #: mzk202303
• Status: Completed
• Start date: December 1, 2018
• Est. completion date: July 31, 2023

Study information

• Verified date: August 2023
• Source: Wuhan Union Hospital, China
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Retrospective collection of Wuhan Union hospital from December 1,2018 to June 30,2021 to meet the entry and discharge standards. The patient 's medical record data were divided into study group and control group according to the use of gastrodin during operation. The perioperative data and prognostic outcomes in the patient 's medical records were collected and analyzed. The degree of myocardial injury and postoperative clinical outcomes were compared between the two groups.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 160
• Est. completion date: July 31, 2023
• Est. primary completion date: June 30, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients aged=18 years, regardless of gender;

• Patients undergoing elective cardiac surgery under general anesthesia;

• ASA grade 1 ~ 3.

Exclusion Criteria:

• Suffering from more serious genetic diseases (such as immunodeficiency, thalassemia, etc.);

• Moderate to severe malnutrition, moderate to severe anemia;

• Persistent infection;

• Severe preoperative underlying diseases (such as severe liver and kidney dysfunction)

Related Conditions & MeSH terms

• Cardiac Surgical Procedures

Locations

Country	Name	City	State
China	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Wuhan	Hubei

Sponsors (1)

Lead Sponsor	Collaborator
Wuhan Union Hospital, China

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The degree of myocardial injury	The myocardial tissue trimmed by the surgeon according to the surgical requirements was collected during the operation for electron microscopy observation and detection of related molecular content.	The myocardial tissue was collected during the operation. About 2 hours on average