Effect of the Combined Programme on Perioperative Anaemia（CPPA）

Status Recruiting

Clinical Trial Summary

We used the preoperative intervention of iron sucrose in combination with human erythropoietin and vitamin C as an innovative combination therapy. This combined treatment strategy aims to improve perioperative anaemia in patients by promoting erythropoiesis and improving iron metabolism. Compared with previous perioperative intravenous iron supplementation, this innovative combination therapy strategy takes into account multiple aspects of iron metabolism as well as the biological mechanisms of erythropoiesis, providing a more comprehensive intervention. Management of perioperative anaemia in previous studies has largely relied on single intravenous iron supplementation therapy, and although this approach has been effective in raising iron levels, its effectiveness may be limited in patients who have impaired iron utilisation or in situations where concurrent stimulation of erythropoiesis is required. The use of iron sucrose in combination with human erythropoietin and vitamin C, on the other hand, is based on an integrative therapeutic concept aimed at providing a more comprehensive response to perioperative anaemia by simultaneously promoting effective iron utilisation and erythropoiesis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05353348
Study type	Interventional
Source	Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact	Min Yan
Phone	13757118632
Email	zryanmin@zju.edu.cn
Status	Recruiting
Phase	N/A
Start date	March 15, 2023
Completion date	December 31, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05054179` - Pecto-Intercostal Fascial Plane Block Catheter Trial for Reduction of Sternal Pain	Phase 2/Phase 3
Completed	`NCT04051021` - Non-Pharmacological Interventions on Patient Experience and Healthcare Utilization in Adult Cardiac Surgery Patients	N/A
Recruiting	`NCT04604886` - The Consistency of Cardiac Output Measured by Pulmonary Artery Catheter and LiDCO in Cardiac Surgical Patients	N/A
Recruiting	`NCT04075981` - Prevention Atrial Fibrillation by BOTulinum Toxin Injections (BOTAF)	Phase 3
Completed	`NCT04062396` - Comparison of Remowell 2 and Inspire on Delirium and Cognitive Dysfunction	N/A
Recruiting	`NCT04709705` - DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)	Phase 2/Phase 3
Not yet recruiting	`NCT05563662` - SURgical Registry of ENDocarditis EuRope
Withdrawn	`NCT03289104` - Improving Sternal Healing After Cardiac Surgery: Sternal Wire vs ZIPFIX	N/A
Completed	`NCT03563196` - Diagnosis Of Pulmonary Complications After Cardiac Surgery In Children
Completed	`NCT04199039` - Effects of Endotracheal Tube Fixation Methods on Hemodynamic Parameters During Endotracheal Suction	N/A
Completed	`NCT02964026` - Study of Clinical Outcomes Associated With the Pulmonary Artery Catheter (PAC) in Cardiac Surgery Patients	N/A
Completed	`NCT02471001` - The Levels of Anaesthetics in Heart Muscle During Heart Surgery	N/A
Completed	`NCT02325726` - RRI Compared With NephroCheckTM to Predict Acute Renal Failure After Cardiac Surgery.	N/A
Completed	`NCT01246947` - Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation	N/A
Completed	`NCT01151254` - Comparison of Propofol Based Versus Volatile Based Anesthesia and Postoperative Sedation	N/A
Completed	`NCT00996099` - Continuous Glucose Monitoring Combined With Computer Algorithm for Intensive Insulin Therapy in Cardiosurgical Patients	N/A
Completed	`NCT00821262` - Sevoflurane in Cardiac Surgery	Phase 4
Completed	`NCT00617955` - Effects of Aprotinin During Cardiac Surgery/Long Term Death Rates	N/A
Completed	`NCT00336466` - The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS)	Phase 2
Completed	`NCT00337805` - Double Blind Randomized Trial of Saline vs Pentaspan for Resuscitation After Cardiac Surgery	Phase 2/Phase 3