Cardiac Surgery Clinical Trial
Official title:
Study of the Expression of Endoplasmic Reticulum Stress During Extracorporeal Circulation in Humans
The links between systemic inflammation, endothelial dysfunction and endoplasmic reticulum
(ER) stress in pre-clinical models make it an interesting potential therapeutic target, but
there are no data describing SRE during severe inflammation in humans .
For an approach to the study of SRE in humans in a situation of systemic inflammation, the
analysis of patients benefiting from an extra-corporeal circulation for a programmed cardiac
surgery would allow a study under well described conditions of inflammation, standardized,
with the possibility for each patient to be his own witness. Compared to a situation of
secondary inflammation (sepsis, acute pancreatitis, trauma ...) the analysis of the patients
under CEC allows more precise description of the kinetics of the activation of the SRE
because the beginning of the inflammatory mechanism is known with precision.
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