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End-expiratory and End-inspiratory Occlusion Tests to Predict Fluid Responsiveness — EEOFR  

Cardiac Surgery Clinical Trial

Official title:
End-expiratory and End-inspiratory Occlusion Tests to Predict Fluid Responsiveness in Mechanically Ventilated Cardiac Surgical Patients

Clinical Trial Summary

The purpose of the study is to verify the efficacy of using end-expiratory and end-inspiratory occlusion tests as an index of fluid responsiveness in mechanically ventilated patients with cardiac surgery.

Clinical Trial Description

Patients with hypotension after anesthetic induction for cardiac surgery, who requires fluid resuscitation based on clinical judgement by the anesthesiologists are enrolled in this study. Patients are monitored by transesophageal echocardiography and FloTrac/Vigileo. Hemodynamic variables (heart rate, systolic blood pressure, diastolic blood pressure, mean artery pressure, central venous pressure, stroke volume variation, cardiac index, velocity time integral of the aorta etc) are measured at baseline, after end-expiratory occlusion (EEO) test, after end-inspiratory occlusion (EIO) test, after passive legs raising test, and after fluid challenge respectively. Responders are defined by an increase in velocity time integral over 15% after infusion of 5ml/kg of crystalloid solution. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03485833
Study type Interventional
Source Shanghai Zhongshan Hospital
Contact Zhe Luo, PhD
Phone 021-64041990
Email luo.zhe@zs-hospital.sh.cn
Status Recruiting
Phase N/A
Start date January 1, 2018
Completion date December 31, 2020
View Details
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