An Assessment of Pulse Pressure Variation to Guide Fluid Therapy in Cardiac Surgery Patients

Cardiac Surgery Clinical Trial

Official title: A Before-and-after Assessment of Pulse Pressure Variation Guided Fluid Therapy in Cardiac Surgery Patients Receiving Mandatory Mechanical Ventilation

Status Completed

Clinical Trial Summary

We aim to test the hypothesis that fluid therapy based on pulse pressure variation (PPV) in patients after cardiac surgery who are mechanically ventilated leads to a significant decrease in the amount of fluid given to such patients in the first 24 hours after surgery

Clinical Trial Description

1. The investigators will study patients after cardiac surgery

2. The investigators will collect data on standard care in pre-intervention population

3. The investigators will collect demographic and clinical data

4. The investigators will collect biochemical data in the first 24 hours after surgery

5. The investigators will collect biochemical, physiological and clinical outcome data

6. The investigators will compare the standard care and intervention period data ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Cardiac Surgery

• NCT number: NCT01681758
• Study type: Interventional
• Source: Austin Health
• Status: Completed
• Phase: Phase 2
• Start date: January 2012
• Completion date: April 2013