Cardiac Surgery Clinical Trial
Several studies have highlighted the cardioprotective effects of acute normovolemic hemodilution during cardiac surgery. The aim of our study is to show that an increase in endogenous erythropoietin (EPO) might explain the cardioprotective effects of acute normovolemic hemodilution against ischemia-reperfusion phenomena.
The major physiologic function of EPO is thought to be the induction of erythropoiesis.
However, a growing body of evidence indicates that EPO has tissue-protective effects and
prevents tissue damage during ischemia. In an ex vivo proof-of-concept, protective effects
of EPO have been shown in human myocardium.
Several studies have demonstrated that acute normovolemic hemodilution before aortic cross
clamping decreases perioperative myocardial damage. We hypothesized that the onset of acute
anemia increases the endogenous EPO concentration, which explains the cardioprotective
effects of acute normovolemic hemodilution.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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