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NCT00416299 Clinical Trial

Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Cardiac Surgery Clinical Trial

Official title:
Observational Cohort Study on the Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00416299
Other study ID # KliLuNTproBNP
Secondary ID
Status Completed
Phase N/A
First received December 26, 2006
Last updated January 29, 2009
Start date May 2007
Est. completion date August 2007

Study information
Verified date January 2009
Source Klinikum Ludwigshafen
Contact n/a
Is FDA regulated No
Health authority Germany: Federal Institute for Drugs and Medical Devices
Study type Observational

Clinical Trial Summary

To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.

Description:

Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.

Recruitment information / eligibility
Status Completed
Enrollment 100
Est. completion date August 2007
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 75 Years and older
Eligibility Inclusion Criteria:

- patients aged 75 years or older undergoing elective cardiac surgery with CPB

Exclusion Criteria:

- positive cardiac troponin T test within the week before surgery

- patients undergoing emergent procedures

- patients with preoperative mechanical cardiac support

- patients undergoing hemodialysis

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Germany Department of Anesthesiology and Intensive Care Medicine Klinikum Ludwigshafen Ludwigshafen

Sponsors (1)
Lead Sponsor Collaborator
Klinikum Ludwigshafen

Country where clinical trial is conducted

Germany, 

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