Cardiac Surgery Patients Clinical Trial
Official title:
The Neuroprotection of Remote Ischemic Preconditioning on Cardiac Surgery in Multicenter
The current study is designed to clarify the neuroprotective effect of remote ischemic preconditioning on the patients underwent open-heart cardiac surgery.
BACKGROUND: Brain ischemia and injury are commonly contributed to perioperative morbidity
and mortality after cardiac surgery. Remote ischemic preconditioning (RIPC) is a phenomenon
whereby brief periods of ischemia followed by reperfusion in one organ provide systemic
protection from prolonged ischemia. To investigate whether remote preconditioning protects
the brain injury in patients undergoing elective cardiac surgery, a randomized trial will be
performed in current study.
DESIGNING 150 patients will be randomize assigned to cardiac surgery with RIPC or without
RIPC (control). Remote ischemic preconditioning consist of three 5-min cycles of right upper
limb ischaemia, induced by an automated cuff-inflator placed on the upper arm and inflated
to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff is deflated.
Cerebral injury was assessed by S-100b, NSE, and neurological function scores in different
time points.
EXPECTED RESULTS RIPC will reduce the incidence of cerebral injury in cardiac surgery.
CONCLUSIONS:
In patients undergoing elective cardiac surgery, RIPC reduces the incidence of postoperative
cerebral injury.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
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