Clinical Trials Logo
  1. Home
  2. Cardiac Pacing, Artificial
  3. NCT03452462

Electrical Resynchronization and Acute Hemodynamic Effects of Direct His Bundle Pacing Compared to Biventricular Pacing

Cardiac Resynchronization Therapy Clinical Trial

Official title:
Electrical Resynchronization and Acute Hemodynamic Effects of Direct His Bundle Pacing Compared to Biventricular Pacing

Clinical Trial Summary

The aims are to compare Direct His Bundle Pacing (DHBP) with biventricular pacing (BiV) in terms of electrical resynchronization using electrocardiographic imaging (ECGI) and also in terms of acute hemodynamical effect using finger plethysmography and conduction velocimetry. The study will be a randomized crossover design with acute measurements.

Clinical Trial Description

By recruiting native conducting tissue to relay electrical activation of the ventricles via the Purkinje fibre network, DHBP may potentially achieve greater electrical resynchronization and hemodynamic benefit compared to BiV where the electrical activation wavefronts propagate from two discrete pacing sites. Electrical synchrony achieved by these pacing modes have however never been compared. Furthermore, the acute hemodynamic effect of DHBP has been compared to BiV only in a small single study to date. The aims are to compare DHBP with BiV in terms of electrical resynchronization using electrocardiographic imaging (ECGI) and also in terms of acute hemodynamical effect using finger plethysmography and conduction velocimetry. The primary endpoint will be left ventricular activation time, with secondary endpoints including various electrical (right ventricular activation time, total ventricular activation time etc) and hemodynamic parameters (systolic pressure, cardiac output, cardiac contractility). It is expected that DHBP offers shorter left ventricular activation time (i.e. better synchrony) and hemodynamic benefit compared to BiV. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03452462
Study type Interventional
Source University Hospital, Geneva
Contact
Status Completed
Phase N/A
Start date April 1, 2019
Completion date November 26, 2020
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05564689 - Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy
Completed NCT06444386 - ECGi of SyncAV With MultiPoint Pacing
Recruiting NCT01515761 - POsition of Leads in Advanced heaRt Failure: the POLAR Study N/A
Completed NCT04595305 - Septal Mapping And Resynchronisation Therapy- (SMART) Study N/A
Not yet recruiting NCT05985408 - LVSP Based CRT vs. RVAP Based CRT N/A
Completed NCT04065893 - Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy
Completed NCT04505384 - Acute Effects of LBBP Versus BVP for CRT N/A
Suspended NCT04347109 - cArdiac Non Invasive MApping in resynchronizaTION
Recruiting NCT02962791 - Prospective Randomized Trial Comparing TRIPLE Site ventriculAr Stimulation Versus Conventional Pacing in CRT canDidates N/A
Recruiting NCT03587064 - Comparison of CRT-D and CRT-DX Systems (CRT-NEXT) N/A
Recruiting NCT03301363 - Simultaneous or Sequential Multipoint Pacing
Recruiting NCT06105580 - Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant N/A
Recruiting NCT03415945 - Left Ventricular Septal Pacing: Potential Application for Cardiac Resynchronization Therapy N/A
Completed NCT04299360 - Comparison of Multi-point Pacing and Conventional CRT Through Non-invasive Hemodynamics Measurement and Global Longitudinal Strain Assessment
Suspended NCT02728336 - MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT) N/A
Completed NCT00395642 - TRIAGE-CRT Telemonitoring in Patients With CHF and Indication of CRT-D Phase 4
Completed NCT03367104 - Narrow QRS HF Patients Assessed by ECG Belt
Recruiting NCT05971225 - Verifying Remote Monitoring Effect on Net Cardiovascular Outcome; RemoteVerify (RêVe) N/A
Terminated NCT04870281 - Atrial Fibrillation Associated With Heart Failure Treated by BIOTRONIK's CRT-DX System
Recruiting NCT05327062 - Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment N/A