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Methoxyflurane and Fentanyl in LBNP

Analgesia Clinical Trial

Official title:
Methoxyflurane and Fentanyl in the Lower Body Negative Pressure Model of Hypovolemia in Healthy Volunteers; a Randomized, Placebo-controlled Crossover Study

Clinical Trial Summary

The study is a single-centre, placebo-controlled, crossover study on healthy volunteers aiming to explore non-inferiority of methoxyflurane and fentanyl compared to placebo on the tolerance to hypovolemia.

Clinical Trial Description

The study will explore the effects of fentanyl and methoxyflurane versus placebo (NaCl; saline) on the hemodynamic response to hypovolemia in healty volunteers. Hypovolemia will be induced in the "lower body negative pressure" model. XX healthy volunteers will be exposed to inhaled methoxyflurane, 3 ml or intravenous fentanyl, XX mg or placebo in a randomized order (cross-over) at least 3 days apart. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04641949
Study type Interventional
Source Oslo University Hospital
Contact
Status Completed
Phase Phase 4
Start date November 18, 2020
Completion date March 8, 2022
View Details
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