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Cardiac Function clinical trials

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NCT ID: NCT05962190 Recruiting - Adiposity Clinical Trials

Short-term Fat Overfeeding on the Effects of Liver Metabolism

FOS
Start date: February 15, 2023
Phase: N/A
Study type: Interventional

Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk. To explore this, we are undertaking a human in vivo parallel-design study, comparing two isocaloric high-fat diets; one enriched with SFA and the other enriched with unsaturated fatty acids (UFAs), to determine the impact of dietary fat composition on postprandial metabolism, liver fat, cardiac fat and cardiac function.

NCT ID: NCT05698277 Recruiting - Clinical trials for Congenital Heart Defect

Automated Fetal Cardiac Function in Babies Affected by Heart Diseases

Start date: May 1, 2023
Phase:
Study type: Observational

The goal of this international multicentre prospective observational cohort study with a nested case-control study is to test some automated fetal heart functional parameters in healthy babies compared to those affected by a congenital heart condition. The main questions it aims to answer are: - If there is a significant difference between the two populations of infants - Whether these parameters could significantly improve the predictive value of actual cardiovascular profile score to predict hydrops Participants will be offered two automated cardiac function assessments between 27+6 and 29+6 gestational weeks and between 34+6 and 36+6 weeks of gestation. Functional parameters will be compared between the two study groups and evaluated over time.

NCT ID: NCT05662995 Recruiting - Preeclampsia Clinical Trials

Point-of-care Ultrasound Abnormalities in Early Onset Preeclampsia

Start date: November 28, 2022
Phase: N/A
Study type: Interventional

The study is planned to describe the prevalence and severity of cardiac, lung and optic-nerve sheath diameter (ONSD) ultrasound abnormalities in women with early onset preeclampsia with severe features. These findings will be compared with point-of-care ultrasound (POCUS) abnormalities demonstrated in our recent study on late onset preeclampsia. The primary aim of the current study will be to examine the association between pulmonary interstitial edema (PIS), as identified by lung ultrasound, and cardiac dysfunction on echocardiography, and brain natriuretic peptide (BNP), in early onset preeclampsia, after comprehensive echocardiographic assessment. The secondary aims are to assess ONSD, and to explore the association between PIS or ONSD and serum albumin. A further secondary aim will be to explore the association between POCUS abnormalities and cardiotocography abnormalities and early delivery.

NCT ID: NCT04629937 Completed - Cardiac Function Clinical Trials

Evaluation of Whole-body CZT Camera in Gated Tomographic Radionuclide Angiography

STARGAC
Start date: December 30, 2020
Phase: N/A
Study type: Interventional

Tomographic radionuclide angiography (or blood pool) is a reproducible method to evaluate left ventricular ejection fraction that is needed during oncological treatments or to evaluate cardiopathies. Cardiac-dedicated CZT systems allowed dose or time reduction. Multipurpose CZT cameras have not yet been evaluated in this indication. Moreover, the impact of attenuation correction is not known.

NCT ID: NCT04577430 Completed - General Anesthesia Clinical Trials

Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period

Start date: September 8, 2019
Phase: N/A
Study type: Interventional

Perioperative stress may increase the incidence of adverse events in the cardiovascular system and lead to poor prognosis. Dexmedetomidine is a highly selective α2 adrenergic receptor agonist, which can inhibit stress response and reduce hemodynamic fluctuations. In different usage plans, dexmedetomidine can have different effects on hemodynamics, myocardial electrical activity, cardiac function. The main purpose was to observe its effects on myocardial electrophysiology and cardiac function during perioperative period. The secondary purpose was to explore the optimal dose of dexmedetomidine that has the least adverse effects on perioperative electrocardia action and cardiac function

NCT ID: NCT04538079 Terminated - Clinical trials for Hemodynamic Instability

Non-invasive Objective Assessment of Hemodynamics in Preterm Neonates

NOAH
Start date: November 9, 2019
Phase:
Study type: Observational

Study type: Prospective Observational trial Study design: Longitudinal Population: Preterm newborns <32 weeks gestational age Hypothesis: The inclusion of non-invasive physiological measures of cardiac output, peripheral perfusion and brain oxygenation (NIRS) for preterm neonates is feasible and reveals additional information on the hemodynamic status compared to blood pressure alone. These measurements can improve the ability to rapidly identify those infants who might benefit from intervention and are correlated with short term clinical outcomes.

NCT ID: NCT04529187 Completed - Clinical trials for Magnetic Resonance Imaging

Effect of Midazolam and Dexmedetomidine on Heart Function - A Randomized MRI-based Study.

MRI
Start date: January 1, 2018
Phase: Phase 4
Study type: Interventional

To compare the changes in heart function, induced after sedation with midazolam or dexmedetomidine, using cardiac magnetic resonance imaging (MRI). This study is a randomized unmasked study, in which participant will be allocated by the envelop method into the dexmedetomidine (DEX) group or into the midazolam (MID) group.

NCT ID: NCT04455477 Recruiting - Clinical trials for Congestive Heart Failure

Nesiritide for Ventilated Congestive Heart Failure

HENCHF
Start date: May 14, 2020
Phase:
Study type: Observational

The congestive heart failure is a common disease among patients who receive cardiac surgery and may lead to prolonged ventilation support. Nesiritide was a potential therapy for congestive heart failure. This study aimed to compare the Nesiritide induced hemodynamical status changes among congestive heart failure patients with invasive ventilation support.

NCT ID: NCT04287114 Recruiting - Cardiac Function Clinical Trials

Cardiac Stroke Volume at Rest and During Different Exercise Intensities

SVproject
Start date: February 8, 2021
Phase: N/A
Study type: Interventional

The main aim of the present investigation is to study cardiac function in different exercise intensities in healthy human subjects. Two techniques will be used: cardiac ultrasound-derived stroke volume measurements and body impedance measurements. 20 healthy men (n=10) and women (n=10) aged 18-45 years will be investigated at rest and during exercise. All study procedures are non-invasive.

NCT ID: NCT03805776 Recruiting - Anemia Clinical Trials

Intermittent Fasting in Dyslipidemia

Start date: February 20, 2019
Phase: N/A
Study type: Interventional

World Health Organization report notifies of the escalating global burden of cardiovascular diseases (CVD), projecting that it will become the major worldwide cause of death and disability by 2020. The South Asian countries have the highest rates of CVD globally. It is widely acknowledged that South Asians have 40-60% higher risk of CVD linked to mortality, compared with other populations. Multiple human population studies have established the concentration of high density lipoprotein (HDL) cholesterol as an independent, inverse predictor of the risk of having a cardiovascular event. Furthermore, HDLs have several well-documented functions with the potential to protect against cardiovascular disease. This study trial is designed to find out the role of intermittent fasting to improve the dyslipidemia and particularly increase the levels of HDL in general population. Investigators expect that the intermittent fasting will significantly enhance the level of HDL and reduce cardiovascular events in general population.