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Circulating P3NP and Cardiovascular Events in Hemodialysis Patients

Cardiovascular Events Clinical Trial

Official title:
Involvement of Circulating Aminoterminal Propeptide of Type 3 Procollagen in Cardiovascular Events in Patients on Hemodialysis

Clinical Trial Summary

This study evaluates whether circulating levels of aminoterminal propeptide of type III procollagen (PIIINP) can predict the cardiovascular events in hemodialysis patients.

Clinical Trial Description

Type III collagen abundantly exists in the cardiovascular system including the aorta and heart. The aminoterminal propeptide of type III procollagen (PIIINP) is an extension peptide of type III procollagen, which is cleaved off stoichiometrically during conversion from type III procollagen to type III collagen and liberated to serum. Elevated serum concentrations of PIIINP are considered a marker of higher collagen turnover and tissue fibrosis including the heart and vascular system. In this study, the investigators prospectively examined whether serum levels of PIIINP could be a biomarker for predicting cardiovascular events in hemodialysis patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03391128
Study type Observational
Source Toujinkai Hospital
Contact
Status Completed
Phase N/A
Start date January 1, 2005
Completion date January 31, 2005
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