Cardiac Amyloidosis Clinical Trial
Official title:
Cardiac Amyloidosis Registry of University Hospital Leipzig
This is a clinical registry of patients with cardiac amyloidosis being treated at University Hospital Leipzig. The aim of the registry is to collect detailed information about clinical events, symptoms, imaging, biomarkers, comorbidities, and treatment from routine patient management which would not be provided by randomized clinical trails.
Cardiac amyloidosis is increasingly diagnosed since awareness of the disease and therapeutic options increase. There is evidence from clinical trials about warning signs ("red flags"), diagnostic algorithms, and evidence for specific treatment. However, patients in randomized clinical studies are highly selected and do not necessarily reflect clinical practise. Furthermore, large clinical trials do not account for national medical care differences nor provide data about long-term outcome and the associations with comorbidities. Clinical registries may reflect broad clinical practise and help to characterize cardiac amyloidosis in terms of epidemiology, application of diagnostic methods, the impact of comorbidities, and real-world clinical course. Furthermore, clinical registry studies may validate data from randomized clinical trials, provide information on implementation of treatment, the quality of interventions, monitoring patients during treatment, and inform about the safety of procedures. The cardiac amyloidosis registry aims to collect data from the routine clinical management of patients with cardiac amyloidosis at the tertiary care University Hospital Leipzig. In particular, obtaining data about clinical events of heart disease, hemodynamic measures from echocardiography and circulation biomarkers, cardiac morphology from different imaging methods, clinical status, functional capacity, quality of life, and impact of comorbidities during the course of the disease will be the goal of this registry. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04459169 -
Cardiac Amyloidosis : Diagnostic Using Red Flag Signals
|
||
Recruiting |
NCT03029026 -
The Role of Occult Cardiac Amyloid in the Elderly With Aortic Stenosis.
|
||
Recruiting |
NCT06034405 -
Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
|
||
Recruiting |
NCT04915235 -
Prevalence and Prognosis of Cardiac Amiloidosis in Turkey
|
||
Recruiting |
NCT02966522 -
Thalidomide/Dexamethasone Treatment And PET Evaluation In Organ Involvemenet of Cardiac Amyloidosis
|
Phase 2 | |
Terminated |
NCT03333551 -
Cardiac Uptake of 18F Florbetapir in Patients Undergoing Chemotherapy
|
Phase 4 | |
Recruiting |
NCT04105634 -
Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients With Light Chain Amyloidosis Using PET/CT
|
Early Phase 1 | |
Recruiting |
NCT05139797 -
Artificial Intelligence Guided Echocardiographic Screening of Rare Diseases (EchoNet-Screening)
|
||
Not yet recruiting |
NCT05593679 -
A Multi-center Cardiac PYP Scan Registry in Taiwan.
|
||
Not yet recruiting |
NCT04146415 -
Diagnosis of Cardiac Amyloidosis With 99mTc-PYP; Comparison Between Planar Imaging, SPECT/CT and Cardiac-dedicated CZT Camera
|
N/A | |
Not yet recruiting |
NCT06427304 -
Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure
|
||
Recruiting |
NCT06469372 -
Cardiac Amyloidosis Discovery Trial
|
N/A | |
Recruiting |
NCT04856267 -
Exploration of Arrhythmia Burden in Cardiac Amyloidosis Using Implantable Loop Recorders
|
||
Completed |
NCT03119558 -
PET/MRI Evaluation of Cardiac Amyloid
|
Early Phase 1 | |
Recruiting |
NCT02798705 -
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis
|
||
Not yet recruiting |
NCT04387344 -
Morpho-functional Cardiac Modifications in Treated Mutated Transthyretin Cardiac Amyloidosis
|
||
Terminated |
NCT01683825 -
Imaging Cardiac Amyloidosis: A Pilot Study Using F-18 Florbetapir Positron Emission Tomography
|
Phase 4 | |
Withdrawn |
NCT04363294 -
Targeted Testing for ATTR Among Aortic Stenosis Patients-Pilot
|
N/A | |
Not yet recruiting |
NCT04661800 -
Study of Olfactory Disorders in Patients With Cardiac Amyloidosis
|
N/A | |
Terminated |
NCT03232632 -
Assessment of Cardiac Fixation During PET Using a New Drug Within Amyloid Cardiac Injuries.
|
Early Phase 1 |