Cardiac Amyloidosis Clinical Trial
Official title:
Molecular Imaging in Cardiovascular Disease Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR): Cardiac Amyloidosis
PET scanning (positron emission tomography) is a well-established technique used to identify
areas of interest within the body. It involves injecting a radioactive tracer which
highlights abnormal areas. It has recently been combined with CT (computed tomography) and
MRI (magnetic resonance imaging) scanning to more accurately identify abnormalities within
the heart. Cardiac amyloidosis, a condition which causes thickening of heart muscle due to
abnormal protein deposits, is of particular interest. There are different forms of this
condition and at present samples of tissue need to be taken and analysed in order to assess
these accurately, which carries risks.
The study makes use of hybrid PET/MR scanning using a designated scanner which enables PET
scanning combined with MRI scanning. The investigators will use a PET tracer which is widely
used in cardiac imaging as it is hoped this will enable characterisation of abnormal areas
within the heart in this condition in a way which hasn't been done before.
All participants will undergo PET scanning, where a radioactive tracer is injected into a
vein before the scan. The radioactive substance only lasts for a short time and is safe,
passed out of the body in urine. If successful, this imaging method will enable us to detect
differences between different forms of cardiac amyloidosis in a non-invasive way, improving
the diagnostic capabilities in this condition.
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