Exercise to Slow Cardiovascular Ageing Progression

Status Recruiting

Clinical Trial Summary

In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.

Clinical Trial Description

Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. At the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function. Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05775484
Study type	Observational
Source	National Heart Centre Singapore
Contact
Status	Recruiting
Phase
Start date	May 1, 2023
Completion date	December 31, 2051

View Details

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