Carcinoma, Small Cell Lung Clinical Trial
Official title:
A Phase II Trial of Irinotecan, Carboplatin, Bevacizumab in the Treatment of Patients With Extensive Stage Small Cell Lung Cancer
This multicenter phase II trial is designed to study the unique combination of chemotherapy (irinotecan./carboplatin) and bevacizumab in the extensive-stage setting. This clinical setting seems ideal for evaluation of the role of bevacizumab in delaying progression and prolonging survival.
Eligible patients will receive 6 courses of irinotecan, carboplatin, and bevacizumab. The
interval between chemotherapy courses will be 28 days. If after 6 courses of treatment,
patient's response is a CR/PR/SD they will continue on Bevacizumab until tumor progression
or up to 6 cycles (6 months) total.
Treatment sequence:
- Irinotecan 60mg/m2 on days 1, 8, and 15
- Carboplatin AUC=4 day 1 only
- Bevacizumab 10 mg/kg days 1 and 15
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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