Ketogenic Diet With Chemoradiation for Lung Cancer (KETOLUNG)

Carcinoma, Non-Small-Cell Lung Clinical Trial

Official title: A Phase I Trial of a Ketogenic Diet With Concurrent Chemoradiation for Non-small Cell Lung Cancer

Status Terminated

Clinical Trial Summary

This study investigates if using a very low carbohydrate diet during combined chemotherapy and radiation therapy is safe and if it can be tolerated by lung cancer patients.

Clinical Trial Description

Standard treatment for lung cancer includes chemotherapy concurrent with radiation therapy (chemoradiation).

This study is a phase I trial to determine the safety of dietary manipulation during chemoradiation for lung cancer. Specifically, pre-clinical data from mouse studies indicates a ketogenic diet increases tumor cell killing.

Participants will:

• Utilize a specialized ketogenic diet designed by bionutritional services of the clinical research unit. This diet begins 2 days before chemoradiation and continues through at least 5 weeks of chemoradiation.

• Have blood drawn for research purposes weekly to determine measurements of oxidative stress

• Have urine collected sporadically through the study to determine measurements of oxidative stress

• Keep a diary of concomitant medications, side effects, and blood sugars

• Have follow-up to monitor for outcomes and overall survival ;

Related Conditions & MeSH terms

• Carcinoma, Non-Small-Cell Lung
• Lung Neoplasms

• NCT number: NCT01419587
• Study type: Interventional
• Source: University of Iowa
• Status: Terminated
• Phase: N/A
• Start date: July 2011
• Completion date: July 11, 2017