Neuroblastoma Clinical Trial
Official title:
Evaluation of Gallium-68 DOTA-TOC Imaging of Somatostatin Receptor Positive Malignancies
This phase I/II trial studies how well gallium Ga 68-DOTA-TOC positron emission tomography (PET)/computed tomography (CT) or PET/magnetic resonance imaging (MRI) works in imaging patients with somatostatin receptor positive tumors. Gallium Ga 68-DOTA-TOC binds to somatostatin receptor positive tumors and can be seen using a PET scan. A PET scan uses a special camera to detect energy given off from gallium Ga 68-DOTA-TOC, to make detailed pictures of areas where material accumulates in the body. Diagnostic procedures, such as gallium Ga 68-DOTA-TOC PET/CT or PET/MRI, may help find and diagnose somatostatin receptor positive tumors and help plan the best treatment.
PRIMARY OBJECTIVES:
I. To determine if gallium Ga 68-DOTA-TOC (gallium-68 labeled DOTA-TOC) results in the
delineation of more lesions than with conventional imaging.
SECONDARY OBJECTIVES:
I. To determine if the incorporation of gallium (Ga)-68 DOTA-TOC PET/CT into the management
decision making process results in a change in stage of the patient.
OUTLINE:
Patients receive gallium Ga 68-DOTA-TOC intravenously (IV) over 1-2 minutes. Within 55-70
minutes, patients then undergo a PET/CT scan over 30-40 minutes or a PET/MRI scan over 50
minutes.
After completion of study, patients are followed up for 2 weeks.
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