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Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning

Hypothermia Clinical Trial

Official title:
Targeted Temperature Management Combined With Hyperbaric Oxygen Therapy in Acute Severe Carbon Monoxide Poisoning: Multicenter Randomized Controlled Clinical Trial (TTM-COHB Trial)

Clinical Trial Summary

This randomized trial will investigate important neurocognitive clinical outcomes of patients with acute severe carbon monoxide poisoning (ASCOP) randomized to receive either therapeutic hypothermia or normothermia combined with hyperbaric oxygen therapy (HBO).

Clinical Trial Description

CO-poisoned patients are identified by medical history and carboxyhemoglobin (CO-Hb) value >5% (>10% in smokers). Patients presenting with acute CO poisoning will receive one HBO. ASCOP is defined as mental status showing response to painful stimulus or unresponsiveness requiring intubation for airway protection and ventilation support at the emerency department, and persistence of depressed mental status despite the HBO. After HBO treatment, eligible patients who provide consent will be randomly allocated to receive hypothermia, or normothermia treatment administered in a open label fashion except for blinding of outcome assessor. Outcome measures will be administered at 1 month and 6 months after CO exposure. In addition, we will examine the differences in serum markers and mortality between the hypothermia and normothermia groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04975867
Study type Interventional
Source Wonju Severance Christian Hospital
Contact Yong Sung Cha, MD
Phone +82-33-741-1615
Email emyscha@yonsei.ac.kr
Status Recruiting
Phase N/A
Start date October 25, 2021
Completion date July 31, 2025
View Details
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