CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients

CAR-T Cell Immunotherapy Clinical Trial

Official title:
Chimeric Antigen Receptor-Modified T Cells for EphA2 Positive Recurrent and Metastatic Malignant Glioma

Status Withdrawn

Clinical Trial Summary

The purpose of this study is to evaluate the safety and effectiveness of CAR-T cell immunotherapy in treating with EphA2 positive malignant glioma patients.

Clinical Trial Description

Chimeric antigen receptor (CAR) is a recombinant receptor with both antigen-binding and T cell activating functions. Chimeric antigen receptor T cell Immunotherapy has more advantages compared with conventional immunotherapy, especially in dealing with patients of hematologic malignancies and solid malignant tumors.This study design a novel specific Chimeric antigen receptor aiming at EphA2 antigen.After CAR-T cell infusion,At periodic intervals, the investigators will evaluate clinical symptoms Improved conditions of this disease.Through this study,the investigators will evaluate the safty and effectiveness of CAR-T cell immunotherapy in treating with EphA2 positive malignant glioma patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02575261
Study type	Interventional
Source	Fuda Cancer Hospital, Guangzhou
Contact
Status	Withdrawn
Phase	Phase 1/Phase 2
Start date	September 2015
Completion date	August 15, 2016

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See also
Status	Clinical Trial	Phase
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Withdrawn	`NCT03252171` - CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients	Phase 1/Phase 2
Withdrawn	`NCT02723942` - CAR-T Cell Immunotherapy for HCC Targeting GPC3	Phase 1/Phase 2