Solid Tumor Clinical Trial
Official title:
Association of Genetic Polymorphisms With Capecitabine-based Chemotherapy Toxicities in Chinese Solid Tumor Patients
Capecitabine is one of the most active agents in the treatment of many kinds of solid tumors.
However, variability in toxicity and response remains a major problem for patients receiving
capecitabine. It is general that there are many factors for individual differences of drugs
in clinical application, of which genetic factors accounted for more than 20%. Toxicities of
capecitabine, such as diarrhea, hand-foot syndrome or anemia, were evaluated for possible
relationship with pharmacogenetic polymorphisms in several pharmacogenomics studies. Due to
the levels of evidence of those studies are low and lack of sufficient research data of
Chinese, it has the important significance in studying individual differences of capecitabine
in toxicities, through the pharmacogenomics research.
The aim of this study is to evaluating the association genetic polymorphisms with
capecitabine-based chemotherapy toxicities in chinese solid tumor patients. By detecting the
gene polymorphism, investigators intend to study the pharmacokinetic/pharmacogenomics (PK-PG)
correlation of capecitabine and provide scientific basis for precise medication guide for
people to use capecitabine.
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