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CAPD-related Peritonitis clinical trials

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NCT ID: NCT04367974 Enrolling by invitation - Clinical trials for CAPD-related Peritonitis

Clinical Pharmacokinetic Study of Ceftazidime and Cefazolin

Start date: June 1, 2020
Phase:
Study type: Observational

Peritoneal dialysis-related peritonitis is a common complication of peritoneal dialysis, which is the main cause of transfer from peritoneal dialysis to hemodialysis. Guidelines for International Society for peritoneal dialysis(ISPD)published in 2016 recommend that timely and adequate use of antibiotics is the most important part of treatment. Empiric treatment should be initiated as soon as possible after obtaining microbiological specimens,then adjust the antibiotics according to culture results and drug sensitivity of bacteria. Intraperitoneal antibiotic can ensure antibiotic concentrations at the local sites of the infection are maximized,however, in patients with renal failure, the investigators should pay attention to the nephrotoxicity caused by the reduction of renal excretion,being guided by Pharmacokinetic/ Pharmacodynamic Principle on antibiotic can develop dosing recommendations to optimize antibiotic efficacy and minimize toxicity. In this study, the investigators aim to detect the concentration of ceftazidime and cefazolin in CAPD patients,so as to analyze the pharmacokinetics parameters and evaluate the rationality of the treatment.