Cerebellar Alterations in Individuals With a Cannabis Use Disorder

Cannabis Clinical Trial

Official title:

Alterations in Cerebellar-dependent Adaptation Due to Cannabis Use Measured With an Explicit-implicit Visuo-motor Learning Paradigm

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02816034
• Other study ID #: CannabinoidsCerebellum
• Status: Completed
• Phase: N/A
• Start date: June 2016
• Est. completion date: April 2017

Study information

• Verified date: November 2018
• Source: Universitat Pompeu Fabra
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate if individuals with a cannabis use disorder have an impaired cerebellar function by assessing possible alterations to their implicit adaptation during a visuomotor rotation task.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: April 2017
• Est. primary completion date: April 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Patients diagnosed with a Cannabis use disorder following Diagnostic and Statistical Manual (DSM-V) criteria.

• Patients screen positive to cannabis in the urine analysis performed a week prior to assessment.

• Right-handed patients.

• Patients provide a signed consent.

Exclusion Criteria:

• Patients with another current substance use disorder (with the exception of tobacco).

• Patients with a visual impairment that has not been corrected.

• Patients with a cognitive impairment such as mental retardation.

• Patients with psychotic disorders.

Related Conditions & MeSH terms

• Cannabis
• Marijuana Abuse

Intervention

Behavioral:
• Visuo-motor rotation
Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.
• Explicit strategy
Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target

Locations

Country	Name	City	State
n/a

Sponsors (3)

Lead Sponsor	Collaborator
Universitat Pompeu Fabra	Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer

References & Publications (2)

Mazzoni P, Krakauer JW. An implicit plan overrides an explicit strategy during visuomotor adaptation. J Neurosci. 2006 Apr 5;26(14):3642-5. — View Citation

Taylor JA, Klemfuss NM, Ivry RB. An explicit strategy prevails when the cerebellum fails to compute movement errors. Cerebellum. 2010 Dec;9(4):580-6. doi: 10.1007/s12311-010-0201-x. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Directional error of hand trajectories towards a target		1 day (a single session)
Secondary	Reaction times		1 day (a single session)
Secondary	Intrinsic Motivational Inventory		1 day (a single session)