Cannabis Clinical Trial
— THC-GenderOfficial title:
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans
| NCT number | NCT02781519 |
| Other study ID # | 1505015940 |
| Secondary ID | |
| Status | Recruiting |
| Phase | Phase 1 |
| First received | |
| Last updated | |
| Start date | June 2015 |
| Est. completion date | December 2024 |
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
| Status | Recruiting |
| Enrollment | 100 |
| Est. completion date | December 2024 |
| Est. primary completion date | June 2024 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 18 Years to 55 Years |
| Eligibility | Inclusion Criteria: - at least one lifetime exposure to cannabis - good physical and mental health Exclusion Criteria: - cannabis naive individuals - major current or recent stressors - taking estrogen supplements or oral contraceptive pills (for women) |
| Country | Name | City | State |
|---|---|---|---|
| United States | Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine | West Haven | Connecticut |
| Lead Sponsor | Collaborator |
|---|---|
| Yale University |
United States,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Rewarding Effects measured by Visual Analog Scale (VAS) | subjective measure of THC induced "high" | changes in "high" assessed over the following timepoints: baseline, +10, +80, and +200 minutes after THC infusion begins | |
| Primary | Verbal Learning: measured by Rey Auditory Verbal Learning Test (AVLT) | measured as delay recall on the AVLT | 25 minutes after THC infusion begins |
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