Cannabis Clinical Trial
Official title:
Dronabinol Interactions in Humans
Marijuana use is a major problem among veterans and non-veterans. A patient's use of
marijuana while engaged in psychotherapy treatment may affect their memory and, therefore,
limit their ability to benefit from treatment. This study is designed to test a new
pharmacotherapy, modafinil, which has the potential to improve memory functioning in
marijuana using individuals.
We hypothesize that modafinil treatment will decrease ratings of drug liking and improve
cognitive measures, especially episodic memory.
The impairment of episodic memory in marijuana abusers has important treatment implications.
Since many treatments, including cognitive-behavioral therapy, strongly utilize episodic
memory, marijuana use during treatment may lead to diminished treatment outcomes. In
addition, lessened response inhibition may lead to elevated rates of drug relapse while in
treatment. Consequently, a treatment which will improve episodic memory and response
inhibition may lead to improved treatment outcomes in marijuana users. One such treatment is
modafinil.This study will be a 4 session within-subjects, double-blind, crossover study
evaluating the impact of modafinil (400 mg/day) on the cognitive, subjective, and
physiological effects of marijuana. Across 4 sessions, subjects will be randomly assigned to
receive either oral placebo, modafinil (400mg), dronabinol (15mg), or dronabinol and
modafinil. Outcome measures will include physiological, cognitive, and subjective drug
effects.
Currently this study complete and has been published.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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