Cannabis Users Clinical Trial
Official title:
Prevalence of Intracranial Arterial Stenosis in Regular Resin of Cannabis Users Compared to Control Subjects: a Preliminary Study of Feasibility
| NCT number | NCT02246140 |
| Other study ID # | 5715 |
| Secondary ID | |
| Status | Recruiting |
| Phase | N/A |
| First received | |
| Last updated | |
| Start date | July 2014 |
| Est. completion date | August 2026 |
There is an association between intracranial arterial stenosis and ischemic stroke in young adults. The aim of this study is to evaluate the prevalence of intracranial arterial stenosis in asymptomatic regular resin of cannabis users in comparison with control subjects.
| Status | Recruiting |
| Enrollment | 60 |
| Est. completion date | August 2026 |
| Est. primary completion date | August 2026 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 18 Years to 45 Years |
| Eligibility | Inclusion Criteria: - regular resin of cannabis users Exclusion Criteria: - taking vasoactive medications - taking other illicit drugs |
| Country | Name | City | State |
|---|---|---|---|
| France | Hôpitaux Universitaires de Strasbourg | Strasbourg, |
| Lead Sponsor | Collaborator |
|---|---|
| University Hospital, Strasbourg, France |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Presence of intracranial arterial stenosis on cerebral MRA | Rate on cerebral MRA the presence of cerebral Intracranial Arterial Stenosis segmental narrowing defined by at least two intra-cranial arteries compared with a cohort of non cannabis controls subjects. | 3 months | |
| Secondary | -Silent ischemic stroke on cerebral MRI | Evaluate on cerebral MRI the presence of sequelae of ischemic stroke defined by a parenchymal hyperintensity in a vascular territory defined on a T2 sequence. | 3 months | |
| Secondary | -new intracranial arterial stenosis at 3 month follow-up | Evaluate a cerebral MRA at 3 months the presence of new intracranial stenosis among cannabis users, according to the prosecution or stopping use | 3 months | |
| Secondary | -Reversibility of intracranial arterial stenosis at 3 month follow-up | Evaluate on cerebral MRA at 3 months reversibility stenosis present at T0 in cannabis users having stopped their consumption | 3 months |