Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)

Cannabis Use Disorder Clinical Trial

Official title:

Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06124846
• Other study ID #: PSYCH-2023-32396
• Status: Recruiting
• Phase: N/A
• Start date: April 1, 2024
• Est. completion date: April 15, 2028

Study information

• Verified date: April 2024
• Source: University of Minnesota
• Contact: Allison Corlett
• Email: corle050[@]umn.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this study is to understand the changes in neural correlates of reward in adolescents with and without Cannabis Use Disorder (CUD). The study will collect functional magnetic resonance imaging (fMRI) data at 3 different timepoints with the primary goals of understanding striatal reward-based activation during a Monetary Incentive Delay Task and fronto-striatal fMRI resting-state functional connectivity. The study will also explore self-reported impulsivity. The long-term goal is to advance scientific understanding of neural changes associated with cannabis abstinence and inter-individual variability that cannot be otherwise measured in preexisting observational cohorts such as the Adolescent Brain Cognitive Development Study. This parallel intervention study will collect fMRI data in adolescents ages 15-18 years old with and without CUD at three different timepoints over the course of their intervention. Utilizing a validated paradigm, adolescents with CUD will be randomized to 6-weeks of either incentivized, biochemically verified abstinence via contingency management or monitoring with no required abstinence. Age- and sex-matched adolescents with no lifetime history of cannabis use will also complete the protocol. Participants will complete 8 study visits (3 with fMRI scans) involving urinalysis to confirm cannabis self-report and measures of impulsivity.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 64
• Est. completion date: April 15, 2028
• Est. primary completion date: April 15, 2028
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 15 Years to 18 Years

Eligibility

Inclusion Criteria:

• Male and female adolescents between the ages of 15 and 18 (inclusive).
• Have a parent or legal guardian who is able and willing to provide written informed consent.
• Competent and willing to provide written informed assent (participants <18) or consent (participants=18).
• Native English speaker.
• Have a parent or legal guardian who is fluent in English.
• Able to commit to 8 study visits in approximately 60 days (6 weeks).
• Able to safely participate in the protocol and appropriate for outpatient level of care, in the opinion of the PI.
• No active psychosis or current use of antipsychotic medications.
• Participants taking psychotropic medications will be included if the medications have been stable for 6 weeks and are expected to remain stable for the duration of their study participation (i.e., through the third MRI).
• For CB-Abst (n=24) and CB-Mon (n=20) groups: at least 5 days of use per week on average in the past two months and meet DSM-V cannabis use disorder (CUD; at least Mild) criteria. Cannabis use reported within seven days of baseline visit. Positive qualitative urine toxicology test at baseline for THC. No immediate plan to discontinue cannabis use.
• For Con (n=20): no lifetime history of cannabis use. Negative qualitative urine toxicology test at baseline for THC. No immediate plans to begin cannabis use.

Exclusion Criteria:

• Past twelve-month history of substance use disorders (except for Cannabis Use Disorder in CB-Abst and CB-Mon), assessed via semi-structured psychodiagnostics interview at baseline.
• Current daily nicotine use (e.g., via electronic and/or combustible cigarettes).
• Contraindications for MRI (ascertained via participant and parent report), including

but not limited to:

1. Metal implants such as surgical clips or pacemakers, or history of working with metal, unless the possibility of a metal fragment can be ruled out by recent orbital scans.

2. Prior head trauma with neurological sequelae.

3. Claustrophobia.

4. Weight incompatible with MRI safety.

5. Pregnancy.

• Previous or current diagnosis of psychosis, cognitive disability, or bipolar disorder.
• Active suicidality.
• Taking a psychotropic medication that has not reached stability criterion (same medication type and dose for 6 weeks with no planned changes over the study period).
• Any other medical or psychiatric condition deemed serious or contraindicated for any study procedures by Dr. Tervo-Clemmens.

Related Conditions & MeSH terms

• Cannabis Use Disorder
• Marijuana Abuse

Intervention

Behavioral:
• CB-Abst
incentivized, biochemically verified abstinence via contingency management
• CB-Mon
monitoring with no required abstinence

Locations

Country	Name	City	State
United States	University of Minnesota	Minneapolis	Minnesota

Sponsors (1)

Lead Sponsor	Collaborator
University of Minnesota

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain activation during Monetary Incentive Delay Task (reward processing)	A neural measure of reward activation will be defined as the difference between reward positive vs negative feedback in the standardized Harvard Oxford Striatal atlas during the MID Task.	baseline, week3, week 6
Primary	Brain connectivity during resting-state functional neuroimaging protocol	A neural measure of reward-circuitry connectivity will be defined as the correlation values between standardized striatal and salience and orbitofrontal and salience cortical networks	baseline, week 3, week 6
Secondary	Self-reported Impulsivity via UPPS-P scale	Self-reported impulsivity will be defined by Total and Premeditation (lack of), Urgency, Sensation Seeking, Perseverance (lack of) scores	baseline, weeks 1,2,3,4,5 and 6