Neural Indices Associated With Relapse in Cannabis Dependence

Cannabis Dependence Clinical Trial

Official title:

Altered Neural Activation Patterns of Emotional Processing in Dependent Cannabis Users Associated With Relapse

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02801422
• Other study ID #: ART_Can_03
• Status: Recruiting
• Start date: February 2016
• Est. completion date: March 2019

Study information

• Verified date: October 2018
• Source: University of Electronic Science and Technology of China
• Contact: Benjamin Becker, PhD
• Phone: +8618584070309
• Email: ben_becker[@]gmx.de
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this fMRI study is to investigate neural indices of relapse in cannabis dependence. The development and maintenance of drug addictions have been associated with deficits in cognitive control, craving and impaired stress regulation. Therefore, neural markers of brain processes underlying the beforementioned components will be studied. Subsequent follow-up drug use interviews will reveal associations between relapse in cannabis dependence and alterations in brain networks of cognitive control, craving and stress.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 75
• Est. completion date: March 2019
• Est. primary completion date: March 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Cannabis Dependence

• 24 hours abstinence

Exclusion Criteria:

• other DSM-4 diagnosis

• neurological disorder

Related Conditions & MeSH terms

• Cannabis Dependence
• Marijuana Abuse
• Recurrence

Intervention

Other:
• fMRI

Locations

Country	Name	City	State
Germany	University of Bonn	Bonn	North Rhine Westfalia

Sponsors (3)

Lead Sponsor	Collaborator
University of Electronic Science and Technology of China	German Research Foundation, University Hospital, Bonn

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	fMRI neural activation patterns of emotional processing	Activation patterns associated with emotion processing, emotion regulation, craving and stress are determined in addicted cannabis users compared to non-using matched control subjects	one time point = fMRI assessment after minimum 24 hours of abstinence
Secondary	Timeline Followback Interviews	Association between fMRI correlates and drug use during follow up preiod as predictor for relapse	one time point = 12 months after fMRI data acquisition