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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT05643443
Other study ID # ORTH 3-3-3-3
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date December 2022
Est. completion date March 2024

Study information

Verified date December 2022
Source Cairo University
Contact Shady Abd ElSalam, PhD
Phone 00201008815748
Email dr.shadyabdelsalam@icloud.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Therefore the aim of the current randomized controlled clinical trial is to investigate the effect of gradually increasing force magnitude versus constant force magnitude on the rate of tooth movement in a canine retraction model, furthermore investigate the effect of the two force systems on the ratio of cytokines and the pain experienced by the patient. Research question: In adult orthodontic patients requiring bilateral maxillary canines retraction, will gradually increasing force magnitudes accelerate the rate of canine retraction in the experimental side when compared to the control side?


Description:

A. -Patient preparation: 1. After patient selection, routine orthodontic records will be collected (study models, panoramic, lateral cephalometric radiographs, and intra-oral and extra-oral photographs). 2. The orthodontic treatment: All subjects will receive a Straight Wire Appliance (SWA); Roth prescription slot 0.022 × 0.028 inch. The brackets will be bonded to the tooth surface using orthodontic light cured composite resin. Ready-made molar bands with 2 buccal tubes (main and auxiliary)1 will be selected, fitted, and cemented on the upper first molars using glass ionomer cement. The arch wire sequence in the initial levelling and alignment stage will be tailored according to the severity of crowding of each case. 3. Just before canine retraction, alginate impressions will be made for the maxillary arch, CGF sample will be taken as described later in the same section, stainless steel arch wire 0.017 x 0.025 mil will be inserted. B. Canine Retraction: 1. The active group (gradually increasing force magnitude) will be randomly assigned to either the patients' left or right sides only (split mouth design). 2. At the start of canine retraction, Nickel-titanium closed-coil springs applying 50 g and 150 g measured using Correx tension gauge will be used in the active side and control sides respectively on each side, stretched bilaterally from the hook on the first molar band to the hook of canine brackets(19). 3. Activation will be done every 4 weeks. 4. The impressions will be poured with dental stone within 15 minutes to ensure its accuracy. 5. Visual analogue scale (VAS) will be explained to the patient and used to measure pain intensity in the postoperative period: immediately after the commencement of canine retraction and at each visit. The patient is asked to make three pain ratings each time to take an average. (one day, second day and one week after)


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 17
Est. completion date March 2024
Est. primary completion date November 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 16 Years to 30 Years
Eligibility Inclusion Criteria: 1. Males and Females with an age ranging between 16-30 years (Adult patients since cooperation increases with age) (17). 2. Malocclusion that requires extraction of the maxillary first premolars and canines retraction with moderate anchorage. 3. Full permanent dentition with exception of the third molars. 4. Good oral hygiene and periodontal condition (Probing depth< 4 mm in all teeth), since the periodontal condition affects the amount and type of tooth movement. 5. Absence of untreated caries which may worsen during the study time. Exclusion Criteria: 1. Medically compromised patients. 2. Patients suffering from any congenital or hereditary diseases. 3. Smoking or any systemic diseases. 4. Chronic use of any medications including antibiotics, phenytoin, cyclosporine, anti-inflammatory drugs, systemic corticosteroids, and calcium channel blockers. All the above factors affect the rate of tooth movement

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Gradual increase of force
steady force

Locations

Country Name City State
Egypt Cairo University Giza

Sponsors (1)

Lead Sponsor Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type Measure Description Time frame Safety issue
Primary Rate of canine retraction mm/time 4 months
Primary change on the Cytokine levels in the gingival crevicular fluid ratio 3 months
Secondary The effect of gradually increasing force magnitude on Pain numeric Pain scale ( 0 as no Pain - 10 As maximum Pain) 4 months
See also
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Completed NCT05872048 - Evaluation of Periodontal Distractor in Acceleration of Canine Retraction N/A
Completed NCT05782088 - Single Versus Repeated Piezocision-assisted Orthodontic Tooth Movement N/A
Recruiting NCT04226469 - Gingival Crevicular Fluid Characterization During Orthodontic Treatment
Terminated NCT03308851 - Evaluation of the Effects of Osteoperforation and Piezocorticision on Canine Retraction N/A
Completed NCT05811728 - Three-dimensional Assessment of the Bone Changes Accompanying Laser-assisted Orthodontic Tooth Movement N/A
Recruiting NCT05780788 - Characterizing Orthodontic Tooth Movement With Photographic Scans N/A
Active, not recruiting NCT05727124 - Poul Gjessing Versus T Loops for Orthodontic Maxillary Canine Retraction N/A
Active, not recruiting NCT06213558 - The Effect of Rectangular Versus Square Archwire on Maxillary Canine Retraction N/A