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Clinical Trial Summary

The purpose of this study is to determine the pharmacokinetics of anidulafungin in intensive care patients.


Clinical Trial Description

Not a lot is known about the pharmacokinetic profile of anidulafungin in IC-patients. IC-patients are at high(er) risk for getting a systemic mould/yeast infection. Anidulafungin is a safe echinocandin with, so far, no reported interactions and few adverse effects. Due to this, anidulafungin is used more often on IC-wards. It is part of the national (Netherlands) IC sepsis protocol. The factors that influence the pharmacokinetics of anidulafungin in IC-patients has not been studied yet. Because these factors are unknown for this population, it is necessary for this research to be done.

Any patient with an (suspected) invasive candidiasis whom is treated with anidulafunging can be includen.

20 patients will be included from 2 different university hospital (10 each). Samples will be taken on different days and timepoints, troughlevels on all treatment days and on treatment day 3 and 7 more samples will be taken voor AUC calculations. ;


Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT01438216
Study type Observational
Source VU University Medical Center
Contact Vera M Middel-Baars, PharmD
Phone +31 20 4445282
Email v.middel-baars@vumc.nl
Status Recruiting
Phase N/A
Start date September 2011
Completion date March 2012

See also
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