Candidemia Clinical Trial
Official title:
Anidulafungin Population Kinetics in the Intensive Care Population
The purpose of this study is to determine the pharmacokinetics of anidulafungin in intensive care patients.
Not a lot is known about the pharmacokinetic profile of anidulafungin in IC-patients.
IC-patients are at high(er) risk for getting a systemic mould/yeast infection. Anidulafungin
is a safe echinocandin with, so far, no reported interactions and few adverse effects. Due
to this, anidulafungin is used more often on IC-wards. It is part of the national
(Netherlands) IC sepsis protocol. The factors that influence the pharmacokinetics of
anidulafungin in IC-patients has not been studied yet. Because these factors are unknown for
this population, it is necessary for this research to be done.
Any patient with an (suspected) invasive candidiasis whom is treated with anidulafunging can
be includen.
20 patients will be included from 2 different university hospital (10 each). Samples will be
taken on different days and timepoints, troughlevels on all treatment days and on treatment
day 3 and 7 more samples will be taken voor AUC calculations.
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Observational Model: Cohort, Time Perspective: Prospective
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