Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation

Candida Infection Clinical Trial

— PERIGLUC1  

Official title:

Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03140748
• Other study ID #: PI2016_843_0036
• Status: Completed
• Phase: N/A
• Start date: May 1, 2018
• Est. completion date: June 1, 2023

Study information

• Verified date: September 2023
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Intraabdominal fungal infections with Candida are constantly increasing. Their diagnosis and treatment is difficult. Morbidity and mortality are high. Β-D-Glucan has been proposed as a marker of systemic fungal infection in candidemia. Moreover, its kinetics is associated with therapeutic success. On the other hand, there are no data on intraabdominal infections that are much more frequent. The objective of the study is to evaluate the initial levels of β-D-glucan and its daily kinetics during the treatment of fungal peritonitis in resuscitation compared to a control group with a yeast-free peritonitis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 70
• Est. completion date: June 1, 2023
• Est. primary completion date: August 22, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Major Patient (age = 18 years)
• Community or associated peritonitis, operated and hospitalized in resuscitation
• Affiliation to a social security scheme

Exclusion Criteria:

• Allergy known to echinocandins
• Dying Patient
• Limitation of care
• Predictable duration of follow-up = 10 days
• Transfusion within 3 months
• Patient minor, patient under guardianship or curatorship

Related Conditions & MeSH terms

• Candida Infection
• Candidiasis
• Peritonitis
• Peritonitis Infectious

Intervention

Other:
• To evaluate the initial levels and kinetics of serum ß-D-glucan
To evaluate the initial levels and kinetics of serum ß-D-glucan during fungal peritonitis compared to a control group of yeast-free peritonitis

Locations

Country	Name	City	State
France	CHU Amiens Picardie	Amiens	Picardie

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood determination of serum ß-D-glucan kinetics in patients with peritonitis	Blood determination of serum ß-D-glucan kinetics in patients with peritonitis	28 days