The Brain Metabolic Change in Chronic Cancer Pain Patient: FDG PET Image Study

Cancer Pain Clinical Trial

Official title:

The Brain Metabolic Change in Chronic Cancer Pain Patient: FDG PET Image Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04255628
• Other study ID #: 201911071RINC
• Status: Recruiting
• Start date: March 2, 2020
• Est. completion date: December 29, 2022

Study information

• Verified date: January 2022
• Source: National Taiwan University Hospital
• Contact: Wen-ying Lin
• Phone: +886972652006
• Email: ying434[@]gmail.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Cancer pain deteriorated in quality of life and related with numerous psychosocial problems. Over the one third of cancer patient suffered from moderate to severe cancer pain, even under adequate pain management.

The 18F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) images can provide quantitative results in clinical oncology. As a functional neuroimaging, the PET evidently provided anatomical activated regions, size, and spatial extent information. In this study, we use FDG-PET to investigate changes concerning the glucose metabolism in the brain with or without cancer pain. Therefore, we may provide useful information to treatment target in cancer pain patients.

Description:

Overall, cancer incidence has decreased and the rate of cancer deaths in both men and women has also significantly declined among both men and women in all site.However, the prevalence of chronic pain is 28.2%, ranging from 22.5% to 35.4%, depending on the location of the primary tumor, and neuropathic characteristics were observed in 19.9% of patients with chronic cancer pain.

Despite numerous studies on cancer pathogenesis and diagnosis, few reports have demonstrated the brain mechanism underlying cancer pain. One study used resting functional magnetic resonance imaging (fMRI) to identify the changes in the functional brain network of chronic bone cancer pain mice under anesthesia. Cancer-induced bone pain (CIBP) might alter resting state activity of the cingulate cortex, prefrontal cortex (PFC) and ventral striatum, indicating a strong affective component of the CIBP mice.In imaging studies of human patients with cancer, patients with chronic cancer pain exhibited activation in the PFC.

The 18F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) images can provide quantitative results in clinical oncology.Owing to the higher glucose metabolic rate in the brain, brain FDG-PET images are not routinely used in the clinical setting. However, several studies have demonstrated functional brain changes in human pain condition.In this study, we use FDG-PET to investigate changes concerning the glucose metabolism in the brain with or without cancer pain.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 120
• Est. completion date: December 29, 2022
• Est. primary completion date: March 28, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

1. Cancer patients who scheduled whole body FDG-PET image scan for clinically indicated.

2. Age > 20

Exclusion Criteria:

1. Unable to complete questionnaires.

2. Prior evidence of brain metastases.

Related Conditions & MeSH terms

• Cancer Pain

Intervention

Diagnostic Test:
• FDG PET
Cancer patients who scheduled whole body FDG-PET image scan for clinically indicated.

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hosipital	Taipei City

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain metabolism change	The FDG-PET of Standardized uptake values (SUVs) were calculated for each voxel in the reconstructed images to investigate changes concerning the glucose metabolism in the brain with or without cancer pain	12 months