Cancer of the PROSTATE Clinical Trial
Official title:
Vessel Sparing Prostate Radiation Therapy: Dose Limitation to Critical Erectile Structures (Corpus Cavernosum and Internal Pudendal Artery) by MRI Based Treatment Planning
Prostate cancer patients have a number of excellent treatment options to consider, and quality of life following treatment is often a consideration in treatment choice. One critical quality of life concern for patients diagnosed with prostate cancer is sexual function. Previous studies point to a vascular mechanism of impotence post-radiation therapy, as opposed to a nerve-based mechanism following surgery. In this study, the critical vascular structures (internal pudendal artery and corpus cavernosum) are defined by MRI-based imaging and included in treatment planning for radiation treatments, hopefully preserving critical artery function. This study will collect erectile function preservation rates at 5-years post-vessel-sparing radiotherapy with or without aids using the patient reported using the simplified three-question erectile function scale.
The vast majority of patients diagnosed with prostate cancer in the modern era of PSA
screening have localized and potentially curable disease. Patients have a number of excellent
treatment options to consider, and quality of life following treatment is often a
consideration in treatment choice. One critical quality of life concern for patients
diagnosed with prostate cancer is sexual function. Studies of sexual function post-radiation
therapy fall into three categories: incidence studies; correlative (dose and toxicity)
studies; mechanism(functional) studies. All these studies point to a vascular mechanism of
impotence post-radiation therapy, as opposed to a nerve-based mechanism following surgery. In
this study, the critical vascular structures (internal pudendal artery and corpus cavernosum)
are defined by MRI-based imaging and included in treatment planning for radiation treatments.
Investigators propose that this technique will improve quality of life, sexual function, and
relapse-free survival.
This study's primary aim is to determine erectile function preservation rates at 5-years
post-vessel-sparing radiotherapy with or without aids using the patient reported using the
simplified three-question erectile function scale.
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