Clinical Trials Logo

Clinical Trial Summary

The main aim of this trial is to assess the response rate, the feasibility and toxicity of the treatment with antigen loaded Dendritic Cell Vaccination in Prostate Cancer patients. Furthermore we want to investigate biological responses by measuring markers of in-vivo and ex-vivo immunomodulation.


Clinical Trial Description

Dendritic cell (DC)-based immunotherapy is a promising approach to augment tumor antigen-specific T cell responses in cancer patients. However, tumor escape with down-regulation or complete loss of target antigens may limit the susceptibility of tumor cells to the immune attack. Concomitant generation of T cell responses against several immunodominant antigens may circumvent this potential drawback. In this phase I/II clinical trial, the investigators determined the immunostimulatory capacity of autologous DC pulsed with multiple T cell epitopes derived from four different prostate-specific antigens in patients with advanced hormone-refractory prostate cancer. Autologous DC of HLA-A*0201-positive patients are loaded with antigenic peptides derived from prostate stem cell antigen, prostatic acid phosphatase, prostate-specific membrane antigen, and prostate-specific antigen. A strict quality control concerning the expression of surface markers and the migratory capacity of the DC secured optimal stimulatory capacity. DC were applied intradermally six times at biweekly intervals followed by monthly booster injections. Tolerability and PSA response will be investigated. Antigen-specific immune responses will be quantified. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01897207
Study type Interventional
Source Cantonal Hospital of St. Gallen
Contact
Status Completed
Phase Phase 1/Phase 2
Start date November 2002
Completion date October 2011

See also
  Status Clinical Trial Phase
Completed NCT03653819 - High Intensity Interval Training (HIIT) for Patients With Cancer-related Lymphedema in the Lower Limbs N/A
Withdrawn NCT05191017 - Study of NUV-422 in Combination With Enzalutamide in Patients With mCRPC Phase 1/Phase 2
Completed NCT00970203 - Dendritic Cell (DC)-Based Vaccines Loaded With Allogeneic Prostate Cell Lines in Combination With Androgen Ablation in Patients With Prostate Cancer Phase 2
Not yet recruiting NCT06363266 - A SMART Design to Optimize the Delivery of TEMPO for Men With Prostate Cancer and Their Caregivers N/A
Active, not recruiting NCT02003924 - Safety and Efficacy Study of Enzalutamide in Patients With Nonmetastatic Castration-Resistant Prostate Cancer Phase 3
Completed NCT00643617 - CyberKnife Radiosurgery For Low & Intermediate Risk Prostate Cancer: Emulating HDR Brachytherapy Dosimetry N/A
Completed NCT00844792 - Study of Antioxidants on Prostate Tumors in Men Undergoing Radical Prostatectomy for Prostate Cancer Phase 2
Completed NCT01303705 - Anti-OX40, Cyclophosphamide (CTX) and Radiation in Patients With Progressive Metastatic Prostate Cancer Phase 1
Completed NCT02578940 - Fluciclovine (18F) PET/CT in biochemicAL reCurrence Of Prostate caNcer Phase 3
Completed NCT04057859 - PCa Patients Managed With ADT to Examine the Effect of Nutritional Guidance and Aerobic/Resistance Fitness Training
Completed NCT00564928 - A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer Phase 2
Completed NCT02958787 - Vessel Sparing Prostate Radiation Therapy Phase 2
Recruiting NCT05241236 - MRI/Ultrasound Fusion Guided Laser Ablation of Prostate Cancer
Active, not recruiting NCT03939689 - Study of I-131-1095 Radiotherapy in Combination With Enzalutamide in Patients With Metastatic Castration-resistant Prostate Cancer Who Are Chemotherapy Naive and Have Progressed on Abiraterone Phase 2
Completed NCT02274350 - The Herlev Hospital Post Radiation Therapy for Localized Prostate Cancer Database for Sexual Side Effects N/A
Completed NCT00744549 - Study of Antioxidants on MRI Detectable Early Stage Prostate Cancer Among Men on Active Surveillance Phase 2
Recruiting NCT05252390 - NUV-868 as Monotherapy and in Combination With Olaparib or Enzalutamide in Adult Patients With Advanced Solid Tumors Phase 1/Phase 2
Completed NCT02212548 - Prostate-Rectal Separation With PEG Hydrogel and Its Effect on Decreasing Rectal Dose N/A
Completed NCT04017325 - European Randomised Study of TOOKAD® Soluble for Prostate Cancer vs Active Surveillance. Post Study Follow-up
Active, not recruiting NCT03238170 - MR-simulation in Radiotherapy for Prostate Cancer N/A