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Clinical Trial Summary

Our goal is to create novel CD47-SIRPα inhibitors using small molecules to reverse TAM-mediated immune suppression and restore anti-tumor immunity in CRCs. Our program uses structure-based drug design to create selective and potent small molecule inhibitors of SIRPα-CD47 to target the tumor microenvironment with greater efficacy and lower toxicity than CD47-targeting antibodies. . In order to study the activity of CD47-SIRPα inhibitors on the immune microenvironment of tumors, we propose to use organoids derived from biopsies of patients with colon cancer. Tumoroids preserve the patient's tumor stroma (including myeloid cells) and provide an accurate in vitro model of complex tumor immune interaction for the evaluation of immunotherapies.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05955196
Study type Observational [Patient Registry]
Source Institut Paoli-Calmettes
Contact Dominique GENRE, MD
Phone +33491223778
Email drci.up@ipc.unicancer.fr
Status Recruiting
Phase
Start date January 9, 2023
Completion date January 9, 2027

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