Cancer of Kidney Clinical Trial
Official title:
A Single Arm Phase 1 Study of Microwave Coagulation Using 2450-MHz Antennae and CO2 Cooling in Partial Nephrectomy for T1 Renal Tumors
Partial nephrectomy (kidney removal) is a standard therapy for clinical T1 renal (kidney)
tumors. The goals of surgery are to accurately remove the tumor with no cancer cells at the
edge of the remaining tissue, to limit blood loss, and preserve kidney function. The most
common technique is to clamp the blood supply to the entire kidney during removal and to
surgically repair the tumor bed with suture and agents to stop bleeding. This stops the blood
supply to the entire kidney including the healthy tissue, which can cause damage to the
remaining tissue due to a shortage of oxygen if left clamped too long.
This study uses a microwave pre-coagulation technique using the Certus 140™ to facilitate a
bloodless area near the tumor for accurate tumor removal and repair, while avoiding clamping
the blood supply, but its effect on the function of kidney adjacent to tumor is unknown. If
adequate stoppage of bleeding is achieved using the Certus 140™ with minimal heat spreading
to the remaining tissue, clamping and a shortage of oxygen can be avoided.
The hypothesis is that microwave pre-coagulation is a safe method for providing the stoppage
of bleeding during partial kidney removal.
n/a
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