Cancer of Gastrointestinal Tract Clinical Trial
Official title:
Rare Subtypes of Gastrointestinal Cancers - Real-world Data and Liquid Biopsies
A single-arm prospective observational translational study of biomarkers in patients receiving targeted treatment for rare subtypes of cancer of the Gastrointestinal Tract.
In this study, the investigators seek to investigate biological aspects in patients receiving targeted treatment for rare subtypes of cancer of the Gastrointestinal. The targeted treatment will be given as per standard of care. Translational blood samples will be drawn pre-treatment, before the third cycle of chemotherapy, and hereafter corresponding to the planned imaging during treatment and follow up. The total cell free DNA will be quantified in all samples. The samples will be analyzed for tumor specific mutations such as the KRAS, BRAF, and NRAS oncogenes, by ddPCR. Circulating tumor DNA will also be identified by hypermethylation markers, and a focused panel of next generation sequencing can be applied. The samples will also be analyzed for immune-related biomarkers. The investigators expect to include up to 130 patients. This is a purely observational translational study. Results will be analysed in relation to outcome data. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04907643 -
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
|
N/A | |
Recruiting |
NCT05179824 -
Tempus Priority Study: A Pan-tumor Observational Study
|
||
Completed |
NCT01730586 -
Abraxane in CIMP-High Colorectal and Small Bowel Adenocarcinomas
|
Phase 2 | |
Withdrawn |
NCT03538613 -
Study of People With Metastatic Gastrointestinal Epithelial Cancer Administering Tumor-Infiltrating Lymphocytes in Which the Gene Encoding CISH Was Inactivated Using the CRISPR/Cas9 System
|
Phase 1/Phase 2 | |
Recruiting |
NCT04426669 -
A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering
|
Phase 1/Phase 2 | |
Recruiting |
NCT01313442 -
Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer
|
||
Withdrawn |
NCT05153304 -
Personalized Immunotherapy in Adults With Upper Gastrointestinal Tract Cancers
|
Phase 1/Phase 2 | |
Withdrawn |
NCT04685759 -
Exercise Regimens and Neoadjuvant Chemotherapy
|
N/A |