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NCT05553080 Clinical Trial

Significance of Immunohistochemical Expression of Fascin-1 in Colorectal Carcinoma

Cancer of Colon Clinical Trial

Official title:
Significance of Immunohistochemical Expression of Fascin-1 in Colorectal Carcinoma

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05553080
Other study ID # Soh-Med-22-09-14
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2022
Est. completion date December 1, 2022

Study information
Verified date October 2022
Source Sohag University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Colorectal carcinoma is a major health problem. As a malignant tumor, the malignant potential of colorectal carcinoma is based mainly on its ability to metastasis to different sites. Fascin-1 is an actin binding protein which is involved in reconstruction of intracellular actin network, the latter enforces the neoplastic cell to invade surrounding structures.

Description:

colorectal carcinoma is an aggressive malignant tumor. It has high incidence of cancer-related morbidity and mortality. the malignant potential of a given neoplasm is based mainly on its ability to invade the surrounding vasculature and reach to distant sites, the latter is called metastasis. in order to metastasize to distant sites, the neoplastic cells must re-arrange the intracellular actin filaments into well formed intracellular assembly which enable the neoplastic cells to reach to distant sites. Fascin-1 is an actin binding protein, it is involved in reconstruction of actin assembly. fortunately, Fascin-1 could be blocked by newly developed medications, blocking of Fascin-1 may limit the metastasis of colorectal carcinoma. in current study the investigators detect Fascin-1 in colorectal carcinoma by immunohistochemical approach, then they correlated different levels of Fascin-1 expression to tumor clinical and pathological criteria as patients' ages, sexes, tumor stages, nodal metastasis, vascular and per-ineural invasions.

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date December 1, 2022
Est. primary completion date September 30, 2022
Accepts healthy volunteers
Gender All
Age group 30 Years to 90 Years
Eligibility Inclusion Criteria: - All cases of colorectal carcinoma. Exclusion Criteria: - cases diagnosed on basis of lower endoscopic biopsies or local resections without radical colectomy. - Patients with preopoerative history of chemo or radiotherapy. - Patients with poor clinical data.

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• Immunohistochemistry
immunohistochemical staining of colorectal carcinoma specimens by anti human fascin antibody.

Locations
Country Name City State
Egypt Maisa Hashem Mohammed Sohag
Egypt Sohag faculty of medicine Sohag

Sponsors (1)
Lead Sponsor Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Evaluation of immunohistochemical staining of colorectal carcinoma by Fascin-1 correlation of different levels of Fascin-1 expression to patients' ages, sexes, tumor stage, nodal metastasis, vascular and perineural invasion. September , 2022
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