Cancer Head Neck Clinical Trial
Official title:
Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal Cancer: Exploring the Impact of Surgical Margins on Local Disease Recurrence: The SCORE Study
Multi-centre retrospective observational cohort study with optional exploratory radiomic study (international) and prospective molecular analysis studies (UK only).
The SCORE study is a international multicentre cohort study investigating the local recurrence free survival outcomes in patients undergoing transoral robotic surgery with and without adjuvant therapy for early stage (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC). Important secondary objectives include assessment of other survival measures (overall, disease free and disease specific), determination of a safe margin "cut off" that minimises the risk of local recurrence, and reporting the rate of early post-operative complications and mortality. Retrospective SCORE patients will optionally contain an exploratory radiomic and radiology morphological analysis to ascertain high risk features of positive margins and local recurrence following TORS for early oropharyngeal cancer. Additionally, the SCORE study will contain a prospective exploratory molecular analysis of consenting patients to help further define OPSCC molecular characteristics in those who experience recurrence and those who do not, in addition to assessing levels of circulating tumour DNA in before and after TORS procedures. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05800834 -
Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds
|
Phase 2 | |
| Recruiting |
NCT06152419 -
Patient Education Videos to Improve Patients' Experience During Radiotherapy Treatment: a National Project
|
N/A | |
| Active, not recruiting |
NCT05987579 -
Surgical Treatment of Stage T3 Squamous Cell Carcinomas of the Scalp
|
||
| Recruiting |
NCT03301493 -
Genomic Testing and Resulting Medical Decisions
|
||
| Not yet recruiting |
NCT05653063 -
ARCHERY - Artificial Intelligence Based Radiotherapy Treatment Planning for Cervical, Head and Neck and Prostate Cancer
|
||
| Completed |
NCT04636723 -
Neuroinflammation in Chronic Systemic Symptoms (CSS)
|
||
| Terminated |
NCT05408871 -
Non-invasive Measurement of PD-L1 Levels With Positron Emission Tomography (PET) in Head and Neck Malignancies and Intracranial Metastases
|
Phase 1 | |
| Recruiting |
NCT04874883 -
Effect of the Use of Symbiotics in Patients With Colon Cancer
|
Phase 4 | |
| Recruiting |
NCT05979883 -
Randomized Evaluation of Machine Learning Assisted Radiation Treatment Planning vs Standard Radiation Treatment Planning
|
N/A | |
| Recruiting |
NCT05745558 -
PREoPerAtive pREhabilitation in Patients With Head and Neck Cancer or Liver Cancer (PREPARE)
|
N/A |