Cancer Colorectal Clinical Trial
Official title:
Post-Operative Exercise Training in Patients With Metastatic Colorectal Cancer
Up to 25% of colorectal cancer (CRC) patients are diagnosed with liver metastases, which is the most common site of metastasis, already during the primary tumor diagnosis. Another 30% of the patients will develop liver metastases at a later stage. Even though patient can be treated by surgical resection of the metastatic tumor, 50-75% of the patients experience a relapse in less than two years. Due to the high probability of relapse, mCRC patients undergo multiple rounds of surgery and adjuvant treatment (chemotherapy/radiotherapy) which results in substantial physical de-conditioning. Physical activity has been shown to increase the progression-free survival rates in mCRC patients, when applied post-diagnosis. Increased cardiorespiratory fitness (VO2peak) at the time of diagnosis among CRC individuals has been associated with lower risk of all-cause mortality. Although data on the effect of chronic exercise on VO2peak have emerged, thus far, there is no randomized clinical trial that has investigated the effects of exercise training in mCRC patients early after surgical treatment with curative intent. Therefore, this project aims to address the beneficial effect of structured exercise training primarily on VO2peak and tumor recurrence in mCRC patients immediately after surgical treatment and while they are undergoing adjuvant chemotherapy/radiotherapy. A total of 66 participants will be recruited from the Department of Surgery and Transplantation, Rigshospitalet and randomly allocated to a standard care control group (n=22), standard care plus 150 min/week exercise training (n=22) or standard care plus 300 min/week exercise training (n=22). Participants will undergo exercise training for 6 months, starting immediately after surgery, and they will be followed for additional 6 months. Tumor recurrence will be evaluated up to 3 years after training initiation.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05536089 -
ctDNA Methylation Application in Postoperative Relapse and Adjuvant Chemotherapy Efficacy Evaluation
|
||
| Active, not recruiting |
NCT04392479 -
TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study.
|
Phase 3 | |
| Not yet recruiting |
NCT05577143 -
Blood Screening for Adult Colorectal Cancer
|
||
| Active, not recruiting |
NCT05585866 -
Propofol and Sevoflurane Anesthesia in Colorectal Cancer Surgery: Incidence of Acute Kidney Injury
|
||
| Recruiting |
NCT05573022 -
Impact of a Patient Decision Aid Intervention
|
N/A | |
| Completed |
NCT02931825 -
Identification of High Risk People for Colorectal Cancer and Evaluation of a Specific Surveillance System
|
N/A | |
| Recruiting |
NCT03301493 -
Genomic Testing and Resulting Medical Decisions
|
||
| Not yet recruiting |
NCT06324409 -
ImmigrantScreen Telephone Reminder Trial in Colorectal Cancer Screening
|
N/A | |
| Not yet recruiting |
NCT05791747 -
Representations, Beliefs and Attitudes Towards Hypnosis in Patients Followed for Colorectal Cancer
|
||
| Recruiting |
NCT05830097 -
A Study of Bi-Ligand-Drug Conjugate CBP-1019 in Patients With Advanced Solid Tumors
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04258813 -
Onco-primary Care Networking to Support TEAM-based Care
|
N/A | |
| Recruiting |
NCT05939440 -
Interventions to Decrease Financial Toxicity
|
N/A | |
| Completed |
NCT04548765 -
Evaluation of Letters Promoting Colorectal Cancer Testing
|
N/A | |
| Recruiting |
NCT04189055 -
Cetuximab as Salvage Therapy in Patients With Neo Wild-type RAS/RAF Metastatic Colorectal Cancer With Liver Metastases.
|
Phase 2 | |
| Recruiting |
NCT04592003 -
French Colorectal ESD Cohort in Experts Centers
|
||
| Withdrawn |
NCT04345952 -
Calm for Cancer Patients Receiving Chemotherapy
|
N/A | |
| Completed |
NCT04280393 -
Effectiveness and Safety of the Colonoscopy Assisted by Endocuff vs. Standard in the Colorectal Cancer Screening
|
N/A | |
| Not yet recruiting |
NCT06231576 -
Digital Home-Based Prehabilitation Before Surgery
|
N/A | |
| Recruiting |
NCT04874883 -
Effect of the Use of Symbiotics in Patients With Colon Cancer
|
Phase 4 | |
| Completed |
NCT04074460 -
Volatile Anaesthesia and Perioperative Outcomes Related to Cancer Feasibility Study
|
Phase 4 |