The Efficacy Of Complete Mesocolic Excision With Central Vessel Ligation Technique On Lymph Nodes And Safety Margins Compared With Conventional Surgery For Colon Cancer Treatment

Cancer Colon Clinical Trial

Official title:

The Efficacy Of Complete Mesocolic Excision With Central Vessel Ligation Technique On Lymph Nodes And Safety Margins Compared With Conventional Surgery For Colon Cancer Treatment

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04079946
• Other study ID #: AssiutU93
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 1, 2019
• Est. completion date: June 1, 2021

Study information

• Verified date: September 2019
• Source: Assiut University
• Contact: Amr E. Hassan, resident Doctor
• Phone: 01004664295
• Email: amrelfayed[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Cancer Colon is one of the major public health problems worldwide. Complete eradication of the tumor with no recurrence or residual masses is a challenge which faces all the surgeons and medical staff all over the world. A lot of techniques were used to ensure 100 % eradication of the tumor and to cure the patients from cancer. Total Mesocolic Excision with Central Vessel Ligation is one of the recent techniques used for colon cancer surgeries. Here in the research the investigators answer the question of how this technique is superior and more beneficial in complete eradication of the tumor than the conventional surgery for colon cancer

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 40
• Est. completion date: June 1, 2021
• Est. primary completion date: December 31, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• • Adult male and female Age of or above 18 years.

• Tumor localization at the caecum, ascending colon, transverse colon, descending colon, sigmoid colon or rectosigmoid on preoperative endoscopy and radiographic imaging [barium enema or computed tomography (CT)]

• No history of familial adenomatous polyposis, ulcerative colitis or Crohn's disease

• Written informed consent

Exclusion Criteria:

• • Contraindications to major surgery and American Society of Anaesthesiologists (ASA) Physical Status scoring 4 which means extreme systemic disorders which have already become an eminent threat to life regardless of the type of treatment.

• Infectious disease requiring treatment.

• Pregnant women

• Use of systemic steroids.

• Severe pulmonary emphysema or pulmonary fibrosis

Related Conditions & MeSH terms

• Cancer Colon
• Colonic Neoplasms

Intervention

Procedure:
• Total Mesocolic Excision with Central Vessel Ligation
sharp dissection of the anatomical layers and the dissection of the visceral plane from the parietal one . In addition a central division of the feeding arteries at their origins is performed at the level of superior mesenteric artery for tumors of the right colon and at the level of inferior mesenteric artery or the aorta for tumors of the left colon .this allows for removal of the maximum number of lymph nodes possible.
• conventional surgery of cancer colon
removal of the tumor with no ligation of the vessel centrally or removal of the whole mesocolon

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Lymph nodes harvest	Number of retrieved lymph nodes can be extracted by this technique	Two years