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Caloric Restriction clinical trials

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NCT ID: NCT04744142 Completed - Ketosis Clinical Trials

Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising strategy to prevent or treat skeletal muscle wasting. Therefore, our aim is to investigate the effect of 3HHB intake on muscle wasting and its adverse consequences during a period of caloric restriction in lean females. In addition, we compare the effects of 3HHB intake with a high protein diet, which is currently considered as the best strategy to minimize lean loss during hypo-energetic periods. To end, we aim to investigate the synergistic effects of the intake of 3HHB in combination with a high protein diet.

NCT ID: NCT04120363 Completed - Sleep Clinical Trials

Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations

OPS II
Start date: September 23, 2019
Phase: Phase 4
Study type: Interventional

The objective of this study is to determine the effects of a single dose of testosterone undecanoate during and in recovery from simulated operational stress.

NCT ID: NCT04042415 Recruiting - Clinical trials for Multiple Sclerosis, Relapsing-Remitting

Calorie Restriction in Multiple Sclerosis

Calorie-MS
Start date: July 14, 2020
Phase: N/A
Study type: Interventional

There is a strong relationship between metabolic state and immune tolerance through a direct control exerted on immune cells by specific intracellular nutrient-energy sensors. An increased "metabolic work load" represents a novel issue linking metabolism with loss of self-immune tolerance. Several disease-modifying drugs have been approved for Relapsing-remitting Multiple Sclerosis (RR-MS) treatments and have shown to reduce relapse rates by modulating immune responses; however, their impact on long-term disease progression and accrual of irreversible neurological disability remains largely unclear, underlining the need for novel therapeutic strategies. In this context, both acute fasting (AF) and chronic caloric restriction (CR) have been shown to improve experimental autoimmune encephalomyelitis (EAE). Despite this evidence, no specific studies have been performed to dissect at the cellular level the mechanism of action of CR in the context of autoimmunity and MS. This study aims at investigating this specific point in order to pave the way for a wider utilization of a nutritional approach to alter MS progression and activity. The aim of this study is to improve the outcome of RR-MS and the efficacy of first line drug treatments (ie. Copaxone or Tecfidera) by altering the metabolic state of the host via calorie restriction with the aim to re-equilibrate immune/inflammatory responses of patients.

NCT ID: NCT03303534 Completed - Carotid Stenosis Clinical Trials

Short-Term Endogenous Hydrogen Sulfide Upregulation

Start date: September 14, 2017
Phase: N/A
Study type: Interventional

This research study will compare the impact of dietary restriction pre-operatively before carotid endarterectomy compared to the standard nutrition that a patient typically eats. The investigators want to find out how patients comply and generally how well patients do with this type of dietary restriction before their surgery since animal studies suggest that short - term dietary restriction may be beneficial before surgery.

NCT ID: NCT02734238 Completed - Exercise Clinical Trials

Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery

OPS
Start date: April 2016
Phase: Phase 4
Study type: Interventional

The objective of this study is to determine whether maintaining a eugonadal state, during severe, sustained energy deficit, attenuates physiological decrements, particularly the loss of lean body mass.

NCT ID: NCT01408784 Recruiting - Caloric Restriction Clinical Trials

A New Method for Self-assessment of Daily Calorie Intake

Start date: July 2011
Phase: N/A
Study type: Observational

The purpose of this study is to assess the validity of self-caloric evaluation, the "categories method" - a new method based on one categorical score per meal