Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU)

Status Completed

Clinical Trial Summary

Martorell hypertensive ischemic leg ulcer is a severe type of skin necrosis (skin infarction) which occurs in long-term hypertensive subjects. Calciphylaxis (calcific uremic arteriolopathy) is a severe type of skin necrosis (skin infarction) which occurs in subjects with end-stage kidney disease or after kidney transplantation.

Clinical Trial Description

Comparative study including - 20 consecutive patients with Martorell HYTILU - 10 consecutive patients with Calciphylaxis (calcific uremic arteriolopathy) - 20 patients with venous ulcer The following parameters are measured in the blood serum: White blood count; c-reactive protein; creatinine; calcium (total); free (ionized) calcium; phosphate; albumin; 25-hydroxyvitamin-D; 1-25-dihydroxyvitamin-D; homocysteine; cystatin C alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1) The following parameters are measured in samples of diseased (necrobiotic) skin: alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01578382
Study type	Observational
Source	University of Zurich
Contact
Status	Completed
Phase
Start date	September 2011
Completion date	December 2019

View Details

See also
Status	Clinical Trial	Phase
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Terminated	`NCT03150420` - A Phase 3 Clinical Trial of Intravenous Sodium Thiosulfate in Acute Calciphylaxis Patients	Phase 3
Completed	`NCT02790073` - Phase 2 Study With SNF472 in Calciphylaxis Patients	Phase 2
Recruiting	`NCT03146793` - The Early Administration of Sodium Thiosulfate Should Help to Reduce the Mortality of Dialysis Patients With Calciphylaxis, From a National Cohort	N/A
Completed	`NCT02278692` - Evaluation of Vitamin K Supplementation for Calcific Uremic Arteriolopathy	N/A
Completed	`NCT02854046` - Calciphylaxis : Population, Risk Factors, Diagnostic Practice, Therapeutic and Outcome
Terminated	`NCT02527213` - Randomized Double Blind Placebo Controlled Trial of Sodium Thiosulfate for the Treatment of Pain Associated With Calcific Uremic Arteriolopath	Phase 3
Recruiting	`NCT03032835` - Partners Calciphylaxis Biobank
Completed	`NCT01289626` - Efficacy of Lanthanum Carbonate in Calciphylaxis	Phase 1
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Completed	`NCT04195906` - Phase 3 Study of SNF472 for Calciphylaxis	Phase 3
Recruiting	`NCT02635373` - European Calciphylaxis Registry Network	N/A
Recruiting	`NCT05018221` - Better Evidence and Translation for Calciphylaxis	Phase 3