Phase II Study of Calcitonin for Tumoral Calcinosis

Status Completed

Clinical Trial Summary

OBJECTIVES: I. Determine whether intermittent, long-term, subcutaneous administration of calcitonin increases phosphaturia, reduces hyperphosphatemia, and increases intact parathyroid hormone levels in patients with tumoral calcinosis.

II. Determine whether calcitonin reduces or prevents tumor recurrence. III. Determine whether hyperphosphatemia abolishes the normal circadian pattern of serum phosphorus.

IV. Determine how repetitive calcitonin administration alters the biochemical markers of bone metabolism in osteopenic patients with tumoral calcinosis.

Clinical Trial Description

PROTOCOL OUTLINE: Patients are treated with subcutaneous injections of salmon calcitonin every 3 weeks. Ondansetron premedication and intravenous hydration are also administered.

Patients are followed for disease progression and tumor recurrence. ;

Study Design

Primary Purpose: Treatment

Related Conditions & MeSH terms

Calcinosis

Clinical Trial Details

NCT number	NCT00004358
Study type	Interventional
Source	National Center for Research Resources (NCRR)
Contact
Status	Completed
Phase	Phase 2
Start date	November 1992

View Details

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