Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy

Bypass Complications Clinical Trial

Official title:

The Difference Between Central and Peripheral Arterial Blood Oxygen Saturation in Patients Undergoing Cardiac Surgery With Different Cardiopulmonary Bypass Strategy

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT01698853
• Other study ID #: 192837
• Status: Not yet recruiting
• Phase: N/A
• First received: September 25, 2012
• Last updated: September 29, 2012
• Start date: October 2012
• Est. completion date: May 2013

Study information

• Verified date: September 2012
• Source: Xijing Hospital
• Contact: Min Chen, M.D.
• Phone: 86-13991221157
• Email: chenminh[@]yahoo.com.cn
• Is FDA regulated: No
• Health authority: China: Ethics Committee
• Study type: Observational

Clinical Trial Summary

Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.

Arterial blood gas analysis can help to detect hypoperfusion or hypoxia during retrograde perfusion. However,whether the arterial oxygenation status from different parts of the body are the same in the condition of retrograde perfusion have not been studied.

The present study is aimed to determine if there is difference in the arterial oxygenation between peripheral arterial and aortic root during the period of retrograde perfusion.In addition, the impact of artificial ventilation on the difference of arterial oxygenation will also be investigated.

Description:

All patients included will be assigned into two different groups according to the surgical approach,one group is named "NP" with normal perfusion,and the other is named "RP" with retrograde perfusion.

For all the patients,we will obtain 0.5ml blood from both peripheral arterial and aortic root for blood gas analysis at some specific time points.

We will focus on the differences of arterial oxygenation between peripheral arterial and aortic root at each group.At the same time,we will analyse the impact of artificial ventilation on it.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: May 2013
• Est. primary completion date: March 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• age > 18 years old

• undergoing totally thoracoscopic cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

• without informed consent

• pregnancy

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Bypass Complications
• Disorder of Blood Gas

Locations

Country	Name	City	State
China	Department of Anesthesiology, Xijing Hospital	Xi'an	Shaanxi

Sponsors (1)

Lead Sponsor	Collaborator
Xijing Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The difference between peripheral arterial oxygenation and aortic root blood oxygenation	The three time points for blood sample collection are:1.right before clamping the aorta; 2.Three minutes after **** without ventilation;3.5 min after re-initiate mechanical ventilation.	patients will be followed up during the cardiopulmonary bypass. Blood samples will be collected at 3 timepoints which is specified in the DESCRIPTION	Yes