Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
wound size |
photos will be taken every day to determine the wound size |
21 days |
|
Primary |
bulla |
examination of the skin at the light microscopic level. Bulla will be considered as present or absent. |
3rd day of the research |
|
Primary |
bulla |
examination of the skin at the light microscopic level. Bulla will be considered as present or absent. |
7th day of the research |
|
Primary |
bulla |
examination of the skin at the light microscopic level. Bulla will be considered as present or absent. |
14th day of the research |
|
Primary |
bulla |
examination of the skin at the light microscopic level. Erythemawill be considered as present or absent. |
21st day day of the research |
|
Primary |
edema |
examination of the skin at the light microscopic level. Edema will be considered as present or absent. |
3rd day of the research |
|
Primary |
edema |
examination of the skin at the light microscopic level. Edema will be considered as present or absent. |
7th day of the research |
|
Primary |
edema |
examination of the skin at the light microscopic level. Edema will be considered as present or absent. |
14th day of the research |
|
Primary |
edema |
examination of the skin at the light microscopic level. Edema will be considered as present or absent. |
21st day of the research |
|
Primary |
inflammatory cell infiltration |
examination of the skin at the light microscopic level. Inflammatory cell infiltration will be considered as present or absent. |
3rd day of the research |
|
Primary |
inflammatory cell infiltration |
examination of the skin at the light microscopic level. Inflammatory cell infiltration will be considered as present or absent. |
7th day of the research |
|
Primary |
inflammatory cell infiltration |
examination of the skin at the light microscopic level. Inflammatory cell infiltration will be considered as present or absent. |
14th day of the research |
|
Primary |
inflammatory cell infiltration |
examination of the skin at the light microscopic level. Inflammatory cell infiltration will be considered as present or absent. |
21st day of the research |
|
Primary |
necrosis |
examination of the skin at the light microscopic level. Necrosis will be considered as present or absent. |
3rd day of the research |
|
Primary |
necrosis |
examination of the skin at the light microscopic level. Necrosis will be considered as present or absent. |
7th day of the research |
|
Primary |
necrosis |
examination of the skin at the light microscopic level. Necrosis will be considered as present or absent. |
14th day of the research |
|
Primary |
necrosis |
examination of the skin at the light microscopic level. Necrosis will be considered as present or absent. |
21st day of the research |
|
Primary |
ulceration |
examination of the skin at the light microscopic level. Ulceration will be considered as present or absent. |
3rd day of the research |
|
Primary |
ulceration |
examination of the skin at the light microscopic level. Ulceration will be considered as present or absent. |
7th day of the research |
|
Primary |
ulceration |
examination of the skin at the light microscopic level. Ulceration will be considered as present or absent. |
14th day of the research |
|
Primary |
ulceration |
examination of the skin at the light microscopic level. Ulceration will be considered as present or absent. |
21st day of the research |
|
Primary |
angiogenesis |
examination of the skin at the light microscopic level. Angiogenesis will be considered as present or absent. |
3rd day of the research |
|
Primary |
angiogenesis |
examination of the skin at the light microscopic level. Angiogenesis will be considered as present or absent. |
7th day of the research |
|
Primary |
angiogenesis |
examination of the skin at the light microscopic level. Angiogenesis will be considered as present or absent. |
14th day of the research |
|
Primary |
angiogenesis |
examination of the skin at the light microscopic level. Angiogenesis will be considered as present or absent. |
21st day of the research |
|
Primary |
fibroblast proliferation |
examination of the skin at the light microscopic level. Fibroblast proliferation will be considered as present or absent. |
3rd day of the research |
|
Primary |
fibroblast proliferation |
examination of the skin at the light microscopic level. Fibroblast proliferation will be considered as present or absent. |
7th day of the research |
|
Primary |
fibroblast proliferation |
examination of the skin at the light microscopic level. Fibroblast proliferation will be considered as present or absent. |
14th day of the research |
|
Primary |
fibroblast proliferation |
examination of the skin at the light microscopic level. Fibroblast proliferation will be considered as present or absent. |
21st day of the research |
|
Primary |
epithelization |
examination of the skin at the light microscopic level. Epithelization will be considered as present or absent. |
3rd day of the research |
|
Primary |
epithelization |
examination of the skin at the light microscopic level. Epithelization will be considered as present or absent. |
7th day of the research |
|
Primary |
epithelization |
examination of the skin at the light microscopic level. Epithelization will be considered as present or absent. |
14th day of the research |
|
Primary |
epithelization |
examination of the skin at the light microscopic level. Epithelization will be considered as present or absent. |
21st day of the research |
|
Primary |
collagenization |
examination of the skin at the light microscopic level. Collagenization will be considered as present or absent. |
3rd day of the research |
|
Primary |
collagenization |
examination of the skin at the light microscopic level. Collagenization will be considered as present or absent. |
7th day of the research |
|
Primary |
collagenization |
examination of the skin at the light microscopic level. Collagenization will be considered as present or absent. |
14th day of the research |
|
Primary |
collagenization |
examination of the skin at the light microscopic level. Collagenization will be considered as present or absent. |
21st day of the research |
|
Primary |
microorganism colonization |
examination of the skin at the light microscopic level. Colonization will be considered as present or absent. |
3rd day of the research |
|
Primary |
microorganism colonization |
examination of the skin at the light microscopic level. Colonization will be considered as present or absent. |
7th day of the research |
|
Primary |
microorganism colonization |
examination of the skin at the light microscopic level. Colonization will be considered as present or absent. |
14th day of the research |
|
Primary |
microorganism colonization |
examination of the skin at the light microscopic level. Colonization will be considered as present or absent. |
21st day of the research |
|