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Cardiovascular Biomarkers and Lung Edema in Severe Burns Patients — CAROLE  

Burns Clinical Trial

Official title:
The Role of CARdiovascular biOmarkers (NT-pro-BNP and CD146) in Predicting Lung Edema in Severely Burned Patients

Clinical Trial Summary

Burn injury leads to hypovolemic then distributive shock. Fluid resuscitation remains the cornerstone of initial treatment of burn shock. However, fluid rescucitation can lead to fluid overload, which manifests most notably as lung edema.

The peptide NT-pro-BNP, a biomarker of cardiac congestion secreted by the myocardium, as well as plasma CD146, an endothelial factor involved in angiogenesis and a marker of vascular congestion, may help identifying patients with risk of pulmonary edema and hypoxia .

Our hypothesis is that these biomarkers may predict the occurence of pulmonary edema in severe burns patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03271268
Study type Observational
Source Saint-Louis Hospital, Paris, France
Contact Sabri Soussi, MD
Phone 0613064542
Email sabri.soussi@gmail.com
Status Recruiting
Phase N/A
Start date August 6, 2017
Completion date April 6, 2019
View Details
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