Review of Human Herpes Viruses in Burns

Burns Clinical Trial

Official title:

Human Herpes Viruses in Burn Victims: A Systematic Review

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02452229
• Other study ID #: SHC-G-SR-HHV
• Status: Completed
• Phase: N/A
• First received: May 14, 2015
• Last updated: May 19, 2015
• Start date: March 2015

Study information

• Verified date: May 2015
• Source: The University of Texas Medical Branch, Galveston
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.

Description:

This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist.

We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search.

On the PubMed interface, we used the following search terms: ("HSV"[All Fields] OR "herpes"[All Fields] OR "CMV"[All Fields] OR "cytomegalovirus"[All Fields] OR "VZV"[All Fields] OR "varicella-zoster"[All Fields]) AND ("burns"[MeSH Terms] OR "burns"[All Fields] OR "burn"[All Fields] OR "thermal trauma"[All Fields]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A&HCI, CPCI-S.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10267
• Est. primary completion date: May 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Patients who presented with at least 1% TBSA burned

• Patients who presented with a viral infections during their hospitalization

Exclusion Criteria:

• Patients who had no burns

• Patients who had no viral infections during their hospitalization

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

• Burns
• Chickenpox
• Cytomegalovirus
• Herpes Simplex
• Herpes Simplex Virus
• Herpes Zoster
• Human Herpes Virus
• Varicella-zoster Virus
• Virus Diseases

Intervention

Other:
• Review of the Literature for Human Herpes Virus infections
Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface. PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
The University of Texas Medical Branch, Galveston	Shriners Hospitals for Children

References & Publications (1)

Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336-41. doi: 10.1016/j.ijsu.2010.02.007. Epub 2010 Feb 18. Erratum in: Int J Surg. 2010;8(8):658. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence of Human Herpes Virus (HHV) Infections	HHV include the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr viruses (EBV) and human herpes virus 6 to 8	Participants will be followed for the duration of hospital stay, an expected average of 3 months.	No
Secondary	Treatment of Human Herpes Virus (HHV) Infections		Participants will be followed for the duration of hospital stay, an expected average of 3 months.	No