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Fenofibrate and Propranolol in Burn Patients

Burn Clinical Trial

Official title:
Mechanisms of Fenofibrate and Propranolol Alone or Combined in Burn Patients

Clinical Trial Summary

The proposed study will test the hypothesis that Propranolol, fenofibrate and fenofibrate plus propranolol have therapeutic, physiological, and metabolic effects that will improve clinical outcomes, and the long-term recovery, rehabilitation, and QOL in burned patients.

Clinical Trial Description

Determine the clinical benefits and underlying mechanisms whereby the metabolic perturbators fenofibrate and propranolol impact burn patient outcomes. The investigators hypothesize that these metabolic regulators given for one year will maintain body mass, improve muscle function by increasing protein synthesis, augment wound healing, reduce fibrosis, improve cardiovascular function, reduce systemic inflammation, restore insulin sensitivity, and decrease liver dysfunction without the risk of the hypoglycemia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02452255
Study type Interventional
Source The University of Texas Medical Branch, Galveston
Contact
Status Terminated
Phase Phase 2/Phase 3
Start date November 2015
Completion date July 12, 2019
View Details
See also
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